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Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities
dc.contributor.author | Rayavarapu S. | |
dc.contributor.author | Yarla N.S. | |
dc.contributor.author | Kadiri S.K. | |
dc.contributor.author | Bishayee A. | |
dc.contributor.author | Vidavalur S. | |
dc.contributor.author | Tadikonda R. | |
dc.contributor.author | Basha M. | |
dc.contributor.author | Pidugu V.R. | |
dc.contributor.author | Dowluru K.S.V.G.K. | |
dc.contributor.author | Lakappa D.B. | |
dc.contributor.author | Kamal M.A. | |
dc.contributor.author | Md Ashraf G. | |
dc.contributor.author | Tarasov V.V. | |
dc.contributor.author | Chubarev V.N. | |
dc.contributor.author | Klochkov S.G. | |
dc.contributor.author | Barreto G.E. | |
dc.contributor.author | Bachurin S.O. | |
dc.contributor.author | Aliev G. | |
dc.date.accessioned | 2020-09-02T22:26:35Z | |
dc.date.available | 2020-09-02T22:26:35Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1038/s41598-017-05832-w | |
dc.identifier.citation | 7, 1, - | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/5968 | |
dc.description | A new series of phenolic glycoside esters, saccharumoside-B and its analogs (9b-9n, 10) have been synthesized by the Koenigs-Knorr reaction. Antiproliferative activities of the compounds (9b-9n, 10) were evaluated on various cancer cell lines including, MCF-7 breast, HL-60 leukemia, MIA PaCa-2 pancreatic, DU145 prostate, HeLa cervical and CaCo-2 colon, as well as normal human MCF10A mammary epithelial and human peripheral blood mononuclear cells (PBMC) by MTT assay. Compounds (9b-9n, 10) exhibited considerable antiproliferative effects against cancer cells with IC50 range of 4.43 ± 0.35 to 49.63 ± 3.59 μM, but they are less cytotoxic on normal cells (IC50 > 100 μM). Among all the compounds, 9f showed substantial antiproliferative activity against MCF-7 and HL-60 cells with IC50 of 6.13 ± 0.64 and 4.43 ± 0.35, respectively. Further mechanistic studies of 9f were carried out on MCF-7 and HL-60 cell lines. 9f caused arrest of cell cycle of MCF-7 and HL-60 cells at G0/G1 phase. Apoptotic population elevation, mitochondrial membrane potential loss, increase of cytosolic cytochrome c and Bax levels, decrease of Bcl-2 levels and enhanced caspases-9 and -3 activities were observed in 9f-treated MCF-7 and HL-60 cells. These results demonstrate anticancer and apoptosis-inducing potentials of 9f in MCF-7 and HL-60 cells via intrinsic pathway. © 2017 The Author(s). | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.title | Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities | |
dc.type | Article |