Mostrar el registro sencillo del ítem

Radiation-mediated formation of complex damage to DNA: A chemical aspect overview

dc.contributor.authorRavanat J.-L.
dc.contributor.authorBreton J.
dc.contributor.authorDouki T.
dc.contributor.authorGasparutto D.
dc.contributor.authorGrand A.
dc.contributor.authorRachidi W.
dc.contributor.authorSauvaigo S.
dc.date.accessioned2020-09-02T22:26:35Z
dc.date.available2020-09-02T22:26:35Z
dc.date.issued2014
dc.identifier10.1259/bjr.20130715
dc.identifier.citation87, 1035, -
dc.identifier.issn00071285
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5965
dc.descriptionDuring the last three decades, a considerable amount of work has been undertaken to determine the nature, the mechanism of formation and the biological consequences of radiation-induced DNA lesions. Most of the information was obtained via the development of chemical approaches, including theoretical, analytical and organic synthesis methods. Since it is not possible to present all the results obtained in this review article, we will focus on recent data dealing with the formation of complex DNA lesions produced by a single oxidation event, as these lesions may play a significant role in cellular responses to ionizing radiation and also to other sources of oxidative stress. Through the description of specific results, the contribution of different chemical disciplines in the assessment of the structure, the identification of the mechanism of formation and the biological impacts in terms of repair and mutagenicity of these complex radiationinduced DNA lesions will be highlighted. © 2014 The Authors.
dc.language.isoen
dc.publisherBritish Institute of Radiology
dc.titleRadiation-mediated formation of complex damage to DNA: A chemical aspect overview
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84902094657.pdf
Tamaño:
2.062Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem