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Clinical phenotypes in chronic obstructive pulmonary disease [Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?]

dc.contributor.authorRafael Silva O.
dc.date.accessioned2020-09-02T22:26:30Z
dc.date.available2020-09-02T22:26:30Z
dc.date.issued2012
dc.identifier10.4067/S0034-98872012000700016
dc.identifier.citation140, 7, 926-933
dc.identifier.issn00349887
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5940
dc.descriptionChronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, that is defined by the degree of obstruction rendered by the forced expiratory volume in the first second (FEV 1). This is a good parameter to define the severity of the disease but does not account for its heterogeneity and does not provide a good comprehension of its different clinical behaviors and responses to treatment. Therefore, the classification of these patients in different clinical phenotypes has been attempted, trying to search for common clinical behaviors and responses to treatment. These phenoptypes must be validated in longitudinal studies. Some of the phenotypes detected are COPD with chronic respiratory failure and responsive to home oxygen therapy, COPD with upper lobe emphysema and responsive to volume reduction surgery, COPD with frequent exacerbation behavior, COPD resembling bronchitis and responsive to Roflumilast and possibly, COPD with systemic involvement. Historically, the phenotypes pink puffer, blue bloater, chronic bronchitis were defined. In the next years, we will know if the definitions of these phenotypes will aid in the management of patients with COPD.
dc.language.isoen
dc.language.isoes
dc.subjectBronchitis, chronic
dc.subjectPhenotype
dc.subjectPulmonary disease, chronic obstructive
dc.subjectarticle
dc.subjectbronchitis
dc.subjectchronic obstructive lung disease
dc.subjectemphysema
dc.subjectgenetics
dc.subjecthuman
dc.subjectphenotype
dc.subjectseverity of illness index
dc.subjectBronchitis
dc.subjectEmphysema
dc.subjectHumans
dc.subjectPhenotype
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectSeverity of Illness Index
dc.titleClinical phenotypes in chronic obstructive pulmonary disease [Fenotipos clínicos en enfermedad pulmonar obstructiva crónica: ¿volver al futuro?]
dc.typeArticle


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