Role of PPAR γ in the differentiation and function of neurons

dc.contributor.author	Quintanilla R.A.
dc.contributor.author	Utreras E.
dc.contributor.author	Cabezas-Opazo F.A.
dc.date.accessioned	2020-09-02T22:26:28Z
dc.date.available	2020-09-02T22:26:28Z
dc.date.issued	2014
dc.identifier	10.1155/2014/768594
dc.identifier.citation	2014, , -
dc.identifier.issn	16874757
dc.identifier.uri	https://hdl.handle.net/20.500.12728/5931
dc.description	Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases. Recent evidence has showed that the activation of PPARγ pathway promoted neuronal differentiation and axon polarity. In addition, activation of PPARγ using thiazolidinediones (TZDs) prevented neurodegeneration by reducing neuronal death, improving mitochondrial function, and decreasing neuroinflammation in neuropathic pain. In this review, we will discuss important evidence that supports a possible role of PPARγ in neuronal development, improvement of neuronal health, and pain signaling. Therefore, activation of PPARγ is a potential target with therapeutic applications against neurodegenerative disorders, brain injury, and pain regulation. © 2014 Rodrigo A. Quintanilla et al.
dc.language.iso	en
dc.publisher	Hindawi Publishing Corporation
dc.title	Role of PPAR γ in the differentiation and function of neurons
dc.type	Review

Repositorio Académico