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Accessory toxins of vibriopathogens and their role in epithelial disruption during infection

dc.contributor.authorPérez-Reytor D.
dc.contributor.authorJaña V.
dc.contributor.authorPavez L.
dc.contributor.authorNavarrete P.
dc.contributor.authorGarcía K.
dc.date.accessioned2020-09-02T22:26:25Z
dc.date.available2020-09-02T22:26:25Z
dc.date.issued2018
dc.identifier10.3389/fmicb.2018.02248
dc.identifier.citation9, SEP, -
dc.identifier.issn1664302X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5910
dc.descriptionGastrointestinal episodes associated with Vibrio species have been rising worldwide in the last few years. Consequently, it is important to comprehend how occurs the production of diarrhea, to establish new preventive and therapeutic measures. Besides the classical CT and TCP toxins, Zot, RTX, and Ace among others have been deeply studied in V. Cholerae. However, in other Vibrio species of clinical interest, where some of these toxins have been reported, there is practically no information. Zot activates a cascade of signals inside of the cell that increase the permeability of epithelial barrier, while RTX causes depolymerization of the actin cytoskeleton and Ace increases the permeability of intestinal cell monolayers. The goal of this study is to acquire information about the distribution of these toxins in human pathogenic Vibrios and to review the progress in the study of their role in the intestinal epithelium during infection. © 2007-2018 Frontiers Media S.A. All Rights Reserved.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAce
dc.subjectIntestinal epithelia
dc.subjectRTX
dc.subjectTight junctions
dc.subjectToxins
dc.subjectVibrio
dc.subjectZot
dc.subjectace toxin
dc.subjectbacterial toxin
dc.subjectcholera toxin
dc.subjectcholix toxin
dc.subjectheat stable enterotoxin
dc.subjecthemagglutinin
dc.subjectproteinase
dc.subjectrepeats in toxin
dc.subjecttight junction protein
dc.subjecttoxin coregulated pilus
dc.subjectunclassified drug
dc.subjectzonula occludens toxin
dc.subjectcell disruption
dc.subjecthuman
dc.subjectinfection
dc.subjectintestine epithelium
dc.subjectnonhuman
dc.subjectorganismal interaction
dc.subjectpathogenesis
dc.subjectpathogenicity
dc.subjectpermeability barrier
dc.subjectprotein function
dc.subjectReview
dc.subjectVibrio
dc.subjectVibrio cholerae
dc.subjectvibriosis
dc.titleAccessory toxins of vibriopathogens and their role in epithelial disruption during infection
dc.typeReview


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