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Galleria mellonella: A model of infection to discern novel mechanisms of pathogenesis of non-toxigenic vibrio parahaemolyticus strains

dc.contributor.authorPérez-Reytor D.
dc.contributor.authorGarcía K.
dc.date.accessioned2020-09-02T22:26:25Z
dc.date.available2020-09-02T22:26:25Z
dc.date.issued2018
dc.identifier10.1080/21505594.2017.1388487
dc.identifier.citation9, 1, 22-24
dc.identifier.issn21505594
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5909
dc.descriptionVibrio parahaemolyticus is a leading cause of raw seafood-associated bacterial gastroenteritis in the world. Its pathogenesis is likely to be multifactorial, although the most characteristic virulence-associated factors are the toxins TDH and TRH, in addition to the Type-III Secretion System-2, which codes for diverse effectors involved in cytotoxicity and enterotoxicity. However, diarrhea cases produced by clinical strains lacking all of these main virulence factors (non-toxigenic strains) have been reported in many countries and they can represent up to 9-10% of the clinical isolations. So far, although there have been significant advances in the description of the virulence factors of V. parahaemolyticus, the ability of non-toxigenic strains to cause illness is still not completely understood. To elucidate this question it is necessary to have adequate infection models. The susceptibility of G. mellonella to the infection with non-toxigenic strains seems to be the response to identifying new virulence factors and consequently providing new insights into mechanisms of the virulence of non-toxigenic strains. This new model means an invaluable contribution to public health, since the understanding of virulence in strains lacking the traditional major toxins is essential to detect these strains present in waters and marine products and avoid possible food-borne infection. © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.language.isoen
dc.publisherTaylor and Francis Inc.
dc.subjectGalleria mellonella
dc.subjectNon-toxigenic strains
dc.subjectVibrio parahaemolyticus
dc.subjectVirulence
dc.subjecthemolysin
dc.subjectprobiotic agent
dc.subjectvirulence factor
dc.subjectbacterial toxin
dc.subjectbacterial virulence
dc.subjectCaenorhabditis elegans
dc.subjectCampylobacter jejuni
dc.subjectcholera
dc.subjectcytotoxicity
dc.subjectdiarrhea
dc.subjectEditorial
dc.subjectEnterococcus faecalis
dc.subjectestuary
dc.subjectGalleria mellonella
dc.subjectgastroenteritis
dc.subjectgastrointestinal toxicity
dc.subjectinflammation
dc.subjectintestine flora
dc.subjectnonhuman
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.subjectVibrio parahaemolyticus infection
dc.subjectYersinia pseudotuberculosis
dc.subjectanimal
dc.subjecthuman
dc.subjectVibrio parahaemolyticus
dc.subjectvibriosis
dc.subjectvirulence
dc.subjectAnimals
dc.subjectBacterial Toxins
dc.subjectHemolysin Proteins
dc.subjectHumans
dc.subjectVibrio Infections
dc.subjectVibrio parahaemolyticus
dc.subjectVirulence
dc.subjectVirulence Factors
dc.titleGalleria mellonella: A model of infection to discern novel mechanisms of pathogenesis of non-toxigenic vibrio parahaemolyticus strains
dc.typeEditorial


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