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Contribution of Tau pathology to mitochondrial impairment in neurodegeneration

dc.contributor.authorPérez M.J.
dc.contributor.authorJara C.
dc.contributor.authorQuintanilla R.A.
dc.date.accessioned2020-09-02T22:26:01Z
dc.date.available2020-09-02T22:26:01Z
dc.date.issued2018
dc.identifier10.3389/fnins.2018.00441
dc.identifier.citation12, JUL, -
dc.identifier.issn16624548
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5867
dc.descriptionTau is an essential protein that physiologically promotes the assembly and stabilization of microtubules, and participates in neuronal development, axonal transport, and neuronal polarity. However, in a number of neurodegenerative diseases, including Alzheimer's disease (AD), tau undergoes pathological modifications in which soluble tau assembles into insoluble filaments, leading to synaptic failure and neurodegeneration. Mitochondria are responsible for energy supply, detoxification, and communication in brain cells, and important evidence suggests that mitochondrial failure could have a pivotal role in the pathogenesis of AD. In this context, our group and others investigated the negative effects of tau pathology on specific neuronal functions. In particular, we observed that the presence of these tau forms could affect mitochondrial function at three different levels: (i) mitochondrial transport, (ii) morphology, and (iii) bioenergetics. Therefore, mitochondrial dysfunction mediated by anomalous tau modifications represents a novel mechanism by which these forms contribute to the pathogenesis of AD. In this review, we will discuss the main results reported on pathological tau modifications and their effects on mitochondrial function and their importance for the synaptic communication and neurodegeneration. © 2018 Pérez, Jara and Quintanilla.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAlzheimer's disease
dc.subjectMitochondria
dc.subjectSynapse neurodegeneration
dc.subjectSynapsis
dc.subjectTau
dc.subjecttau protein
dc.subjectAlzheimer disease
dc.subjectbioenergy
dc.subjectbrain nerve cell
dc.subjectcell energy
dc.subjectcell function
dc.subjectcell structure
dc.subjectcell transport
dc.subjectdisorders of mitochondrial functions
dc.subjecthuman
dc.subjectmitochondrial dynamics
dc.subjectmitophagy
dc.subjectnerve degeneration
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectprotein modification
dc.subjectReview
dc.titleContribution of Tau pathology to mitochondrial impairment in neurodegeneration
dc.typeReview


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