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Preventive and therapeutic potentials of anthocyanins in diabetes and associated complications

dc.contributor.authorPutta S.
dc.contributor.authorYarla N.S.
dc.contributor.authorEswar Kumar K.
dc.contributor.authorLakkappa D.B.
dc.contributor.authorKamal M.A.
dc.contributor.authorScotti L.
dc.contributor.authorScotti M.T.
dc.contributor.authorAshraf G.M.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSasi Bhusana Rao B.
dc.contributor.authorSarala Kumari D.
dc.contributor.authorReddy G.V.
dc.contributor.authorTarasov V.V.
dc.contributor.authorImandi S.B.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:26:00Z
dc.date.available2020-09-02T22:26:00Z
dc.date.issued2018
dc.identifier10.2174/0929867325666171206101945
dc.identifier.citation25, 39, 5347-5371
dc.identifier.issn09298673
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5862
dc.descriptionDiet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases is to be considered. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries. A large number of bioactive anthocyanins, such as cyanidin, malvidin, delphinidin, pelargonidin, peonidin, petunidin and their metabolites have shown multiple biological activities with apparent effects on glucose absorption, glucose uptake, insulin secretion and sensitivity, on the enzymes involved in glucose metabolism, gene expressions, inflammatory mediators, glucose transporters in progression of diabetes and associated complications, such as diabetic retinopathy, nephropathy, neuropathy and diabetic vascular diseases. The versatility of the anthocyanins provides a promising approach for diabetes management than synthetic drugs. Here we summarize the effect of several anthocyanins on many in vitro, in vivo and clinical studies and also reveal the mechanisms which could prevent or reverse the underlying mechanisms of diabetic pathologies including promotion of antioxidant, antihyperlipidemic, anti-inflammatory and anti-apoptotic activities. © 2018 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAnthocyanins
dc.subjectComplications
dc.subjectDiabetes mellitus
dc.subjectGlucose
dc.subjectanthocyanin
dc.subjectcyanidin
dc.subjectcyanidin 3 arabinoside
dc.subjectcyanidin 3 glucoside
dc.subjectcyanidin 3 o beta glucoside
dc.subjectcyanidin 3 rutinoside
dc.subjectcyanidin 3,5 glucoside
dc.subjectdelphinidin
dc.subjectglibenclamide
dc.subjectglucose
dc.subjectmalvidin chloride
dc.subjectpelargonidin
dc.subjectpelargonidin 3 glucoside
dc.subjectpeonidin 3 glucoside
dc.subjectplant glycoside
dc.subjectprotocatechuic acid
dc.subjectunclassified drug
dc.subjectanthocyanin
dc.subjectcyanidin
dc.subjectdelphinidin
dc.subjecthydroxybenzoic acid derivative
dc.subjectpelargonidin
dc.subjectprotocatechuic acid
dc.subjectantiinflammatory activity
dc.subjectantineoplastic activity
dc.subjectantioxidant activity
dc.subjectapoptosis
dc.subjectAristotelia chilensis
dc.subjectAronia melanocarpa
dc.subjectAsystasia gangetica
dc.subjectaubergine
dc.subjectberry
dc.subjectbilberry
dc.subjectblack currant
dc.subjectblackberry
dc.subjectcherry
dc.subjectcranberry
dc.subjectdiabetic complication
dc.subjectdiabetic retinopathy
dc.subjectdisease association
dc.subjectdisease course
dc.subjectenzyme activity
dc.subjectFicus
dc.subjectFicus bengalis
dc.subjectflower
dc.subjectfruit color
dc.subjectglucose absorption
dc.subjectglucose level
dc.subjectglucose metabolism
dc.subjectglucose transport
dc.subjecthuman
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectinsulin release
dc.subjectinsulin sensitivity
dc.subjectkidney disease
dc.subjectluminescence
dc.subjectlychee
dc.subjectMorus nigra
dc.subjectmulberry
dc.subjectMyrica
dc.subjectMyrica cerifera
dc.subjectOreganum vulgare
dc.subjectplant leaf
dc.subjectplant seed
dc.subjectplant stem
dc.subjectReview
dc.subjectrice
dc.subjectrisk factor
dc.subjectsour cherry
dc.subjectsoybean
dc.subjectstrawberry
dc.subjectsweet cherry
dc.subjectsweet potato
dc.subjectVaccinium arctostaphylos
dc.subjectchemistry
dc.subjectdiabetes mellitus
dc.subjectdiet
dc.subjectdrug effect
dc.subjectfruit
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectAnthocyanins
dc.subjectDiabetes Mellitus
dc.subjectDiet
dc.subjectFruit
dc.subjectHumans
dc.subjectHydroxybenzoates
dc.subjectOxidative Stress
dc.titlePreventive and therapeutic potentials of anthocyanins in diabetes and associated complications
dc.typeReview


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