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Brucella canis induces canine CD4 + T cells multi-cytokine Th1/Th17 production via dendritic cell activation

dc.contributor.authorPujol M.
dc.contributor.authorBorie C.
dc.contributor.authorMontoya M.
dc.contributor.authorFerreira A.
dc.contributor.authorVernal R.
dc.date.accessioned2020-09-02T22:25:59Z
dc.date.available2020-09-02T22:25:59Z
dc.date.issued2019
dc.identifier10.1016/j.cimid.2018.11.017
dc.identifier.citation62, , 68-75
dc.identifier.issn01479571
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5856
dc.descriptionBrucella canis is a small intracellular Gram-negative bacterium that frequently leads to chronic infections highly resistant to antibiotic therapy in dogs. Also, it causes mild human brucellosis compared to other zoonotic Brucella spp. Herein we characterize the cellular immune response elicited by B. canis by analysing human and canine CD4 + T cells after stimulation with autologous monocyte-derived dendritic cells (MoDCs). Human and canine B. canis-primed MoDCs stimulated autologous CD4 + T cells; however, a Th1 response was triggered by human MoDCs, whereas canine MoDCs induced Th1/Th17 responses, with increased CD4 + T cells producing IFN-γ and IL-17A simultaneously. Each pattern of cellular response may contribute to host susceptibility, helping to understand the differences in B. canis virulence between these two hosts. In addition, other aspects of canine immunology are unveiled by highlighting the participation of IL-17A-producing canine MoDCs and CD4 + T cells producing IFN-γ and IL-17A. © 2018 Elsevier Ltd
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectBrucella canis
dc.subjectCD4 + T cells
dc.subjectCytokines
dc.subjectDendritic cells
dc.subjectHost susceptibility
dc.subjectgamma interferon
dc.subjectinterleukin 12
dc.subjectinterleukin 17
dc.subjecttumor necrosis factor
dc.subjectbiological marker
dc.subjectcytokine
dc.subjectanimal cell
dc.subjectArticle
dc.subjectbacterial strain
dc.subjectbacterial virulence
dc.subjectBrucella canis
dc.subjectCD4+ T lymphocyte
dc.subjectcell activation
dc.subjectcell isolation
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdendritic cell
dc.subjectdog breed
dc.subjectfemale
dc.subjecthost susceptibility
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmune response
dc.subjectmale
dc.subjectmonocyte
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectTh1 cell
dc.subjectTh17 cell
dc.subjectanimal
dc.subjectbiosynthesis
dc.subjectBrucella canis
dc.subjectbrucellosis
dc.subjectCD4+ T lymphocyte
dc.subjectcell communication
dc.subjectdendritic cell
dc.subjectdog
dc.subjectdog disease
dc.subjectimmunology
dc.subjectimmunophenotyping
dc.subjectlymphocyte activation
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectphysiology
dc.subjectTh1 cell
dc.subjectTh17 cell
dc.subjectveterinary medicine
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectBrucella canis
dc.subjectBrucellosis
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectCell Communication
dc.subjectCytokines
dc.subjectDendritic Cells
dc.subjectDog Diseases
dc.subjectDogs
dc.subjectHumans
dc.subjectImmunophenotyping
dc.subjectLymphocyte Activation
dc.subjectTh1 Cells
dc.subjectTh17 Cells
dc.titleBrucella canis induces canine CD4 + T cells multi-cytokine Th1/Th17 production via dendritic cell activation
dc.typeArticle


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