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Exercise versus fixed-dose combination therapy for cardiovascular risk factors control and atherosclerotic disease prevention: A network meta-analysis protocol

dc.contributor.authorPozuelo-Carrascosa D.P.
dc.contributor.authorCavero-Redondo I.
dc.contributor.authorFernández Rodríguez R.
dc.contributor.authorPascual Morena C.
dc.contributor.authorSequí-Domínguez I.
dc.contributor.authorMartinez-Vizcaino V.
dc.date.accessioned2020-09-02T22:25:56Z
dc.date.available2020-09-02T22:25:56Z
dc.date.issued2020
dc.identifier10.1136/bmjopen-2019-036734
dc.identifier.citation10, 7, -
dc.identifier.issn20446055
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5843
dc.descriptionIntroduction Despite the consistent evidence of the benefits of physical activity on preventing atherosclerotic cardiovascular diseases (ASCVD) and some cardiovascular risk factors, such as hypertension and dyslipidaemia, the prescription of drugs remains the most widely used approach to prevent ASCVD in clinical settings. The purpose of this study protocol is to provide a meta-synthesis methodology for comparing the effect of fixed-dose combination therapy and physical exercise on controlling cardiovascular risk factors and preventing ASCVD. Methods and analysis This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols and the recommendations of the Cochrane Collaboration Handbook. We plan to conduct a computerised search in Medline, Web of Science, Embase, Cochrane Database of Systematic Reviews and SPORTDiscus from inception to May 2020 for studies testing the effectiveness of physical exercise or fixed-dose combination drug therapy in preventing ASCVD, all-cause and cardiovascular mortality and controlling some cardiovascular risk factors (hypertension and dyslipidaemia). Since performing network meta-analyses (NMA) is a statistical approach that allows direct and indirect comparisons of interventions, where sufficient studies are included, we plan to perform the following NMA comparing the effect of fixed-dose combination therapy and physical exercise interventions on (1) improving lipid profile, (2) reducing blood pressure, (3) preventing cardiovascular events and all-cause and cardiovascular mortality and (4) improving compliance with the therapeutic strategy and reducing adverse events. Ethics and dissemination Ethical approval will not be needed because data included in the NMA will be extracted from published trials that meet accepted ethical standards. The results will be published in academic peer-reviewed journals, and the evidence gathered by this project could be included in the preventive cardiovascular disease guidelines. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.subjectclinical pharmacology
dc.subjectischaemic heart disease
dc.subjectstroke medicine
dc.subjectacetylsalicylic acid
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectaerobic exercise
dc.subjectArticle
dc.subjectblood pressure
dc.subjectcardiovascular disease
dc.subjectcardiovascular mortality
dc.subjectcardiovascular risk
dc.subjectclinical effectiveness
dc.subjectCochrane Library
dc.subjectcohort analysis
dc.subjectcombination drug therapy
dc.subjectcoronary artery atherosclerosis
dc.subjectdata extraction
dc.subjectdisease control
dc.subjectdyslipidemia
dc.subjecteffect size
dc.subjectEmbase
dc.subjectexercise
dc.subjecthuman
dc.subjecthypertension
dc.subjectischemic heart disease
dc.subjectlipid fingerprinting
dc.subjectMedline
dc.subjectmeta analysis
dc.subjectnetwork meta-analysis
dc.subjectpatient compliance
dc.subjectpilates
dc.subjectPreferred Reporting Items for Systematic Reviews and Meta-Analyses
dc.subjectprescription
dc.subjectprimary prevention
dc.subjectprospective study
dc.subjectpublication bias
dc.subjectrandomized controlled trial (topic)
dc.subjectrisk assessment
dc.subjectrisk reduction
dc.subjectsecondary prevention
dc.subjectstretching exercise
dc.subjectsystematic review
dc.subjectTai Chi
dc.subjectWeb of Science
dc.subjectyoga
dc.titleExercise versus fixed-dose combination therapy for cardiovascular risk factors control and atherosclerotic disease prevention: A network meta-analysis protocol
dc.typeArticle


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