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Novel lipophilic analogues from 2,4-D and Propanil herbicides: Biological activity and kinetic studies
dc.contributor.author | Porciuncula L.M. | |
dc.contributor.author | Teixeira A.R. | |
dc.contributor.author | Santos M.F.C. | |
dc.contributor.author | D'Oca M.G.M. | |
dc.contributor.author | Santos L.S. | |
dc.contributor.author | Nachtigall F.M. | |
dc.contributor.author | Orth E.S. | |
dc.contributor.author | D'Oca C.R.M. | |
dc.date.accessioned | 2020-09-02T22:25:54Z | |
dc.date.available | 2020-09-02T22:25:54Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1016/j.chemphyslip.2020.104947 | |
dc.identifier.citation | 231, , - | |
dc.identifier.issn | 00093084 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/5833 | |
dc.description | This work describes the synthesis of new lipophilic amides and esters analogues of classical organochlorides herbicides by incorporation of long-chains from fatty acids and derivatives. The new fatty esters and amides were synthesized in 96–99% and 80–89% yields, respectively. In general, all compounds tested showed superior in vitro activity than commercial herbicides against growth L. sativa and A. cepa, in ranges 86–100% of germinative inhibition. The target compounds showed, significantly more susceptible towards acid hydrolysis than 2,4-dichlorophenoxyacetic acid (2,4-D). The kinetic and NMR studies showed that the incorporation of lipophilic chains resulted in a decrease in half-life time of new herbicides compounds (1.5 h) than 2,4-D (3 h). These findings suggest the synthesis of new lipophilic herbicides as potential alternative to traditional formulations, by incorporation of long fatty alkyl chains in the molecular structure of 2,4-D, resulting in superior in vitro herbicidal activity, best degradation behavior and more hydrophobic derivatives. © 2020 Elsevier B.V. | |
dc.language.iso | en | |
dc.publisher | Elsevier Ireland Ltd | |
dc.subject | 2,4-D | |
dc.subject | Fatty acids | |
dc.subject | Organochlorides herbicides | |
dc.subject | Propanil | |
dc.subject | Renewable resources | |
dc.subject | 2,4 dichlorophenoxyacetic acid | |
dc.subject | fatty acid ester | |
dc.subject | propanil | |
dc.subject | sulfuric acid | |
dc.subject | triethylamine | |
dc.subject | acid hydrolysis | |
dc.subject | aminolysis | |
dc.subject | Article | |
dc.subject | carbon nuclear magnetic resonance | |
dc.subject | catalysis | |
dc.subject | chemical structure | |
dc.subject | controlled study | |
dc.subject | esterification | |
dc.subject | germination | |
dc.subject | herbicidal activity | |
dc.subject | hydrolysis | |
dc.subject | in vitro study | |
dc.subject | kinetics | |
dc.subject | lettuce | |
dc.subject | lipophilicity | |
dc.subject | monocot | |
dc.subject | onion | |
dc.subject | plant growth | |
dc.subject | priority journal | |
dc.subject | proton nuclear magnetic resonance | |
dc.subject | rate constant | |
dc.subject | reaction analysis | |
dc.subject | reaction time | |
dc.subject | stoichiometry | |
dc.subject | synthesis | |
dc.subject | ultraviolet visible spectroscopy | |
dc.title | Novel lipophilic analogues from 2,4-D and Propanil herbicides: Biological activity and kinetic studies | |
dc.type | Article |