Mostrar el registro sencillo del ítem

A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: A longitudinal study

dc.contributor.authorPerez-Cornago A.
dc.contributor.authorDe La Iglesia R.
dc.contributor.authorLopez-Legarrea P.
dc.contributor.authorAbete I.
dc.contributor.authorNavas-Carretero S.
dc.contributor.authorLacunza C.I.
dc.contributor.authorLahortiga F.
dc.contributor.authorMartinez-Gonzalez M.A.
dc.contributor.authorMartinez J.A.
dc.contributor.authorZulet M.A.
dc.date.accessioned2020-09-02T22:25:46Z
dc.date.available2020-09-02T22:25:46Z
dc.date.issued2014
dc.identifier10.1186/1475-2891-13-36
dc.identifier.citation13, 1, -
dc.identifier.issn14752891
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5776
dc.descriptionBackground: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain. Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors. Methods. Sixty subjects (Age: 50 ± 1 y; BMI: 36.1 ± 0.6 kg/m2) with MetS were selected from the RESMENA study (control and intervention) after they completed the 6-months hypocaloric treatment and rated for depressive symptoms using the Beck Depression Inventory (BDI). Anthropometric and biochemical measurements including leptin, C-reactive protein (CRP) and insulin levels were evaluated. Results: Depressive symptoms decreased during the weight loss intervention, with no differences between both dietary groups (control group -4.2 ± 0.8 vs RESMENA group -3.2 ± 0.6, P = 0.490). The number of criteria of the MetS was higher among subjects with more somatic-related depressive symptoms at baseline (B = 1.032, P-trend = 0.017). After six months of dietary treatment, body weight decreased in all subjects (-8.7%; confidence interval (95% CI) = 7.0-9.7) and also self-perceived depression (-37.9%; 95% CI = 2.7-4.9), as well as circulating leptin (-20.1%; 95% CI = 1.8-6.8), CRP (-42.8%; 95% CI = 0.6-3.0) and insulin (-37.7%; 95% CI = 4.1-7.2) concentrations. The decrease in BDI was significantly associated with declines in body fat mass (B = 0.34, 95% CI = 0.11-0.56) and also with the decrease in leptin (B = 0.16, 95% CI = 0.04-0.28) and CRP (B = 0.24, 95% CI = 0.01-0.46) concentrations. Conclusions: The decrease in depressive manifestations after a weight loss intervention was related with adiposity, CRP and leptin in subjects with MetS. Trial registration. ClinicalTrials.gov: NCT01087086. © 2014 Perez-Cornago et al.; licensee BioMed Central Ltd.
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.subjectAdiposity
dc.subjectDepression
dc.subjectHypocaloric diet
dc.subjectInflammation
dc.subjectLeptin
dc.subjectMetabolic syndrome
dc.subjectC reactive protein
dc.subjectinsulin
dc.subjectleptin
dc.subjectC reactive protein
dc.subjectadult
dc.subjectanthropometric parameters
dc.subjectarticle
dc.subjectBeck Depression Inventory
dc.subjectbiochemistry
dc.subjectbody fat
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectfat mass
dc.subjectfemale
dc.subjecthuman
dc.subjectinflammation
dc.subjectlongitudinal study
dc.subjectlow calory diet
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectself concept
dc.subjecttreatment duration
dc.subjectweight reduction
dc.subjectcomplication
dc.subjectdepression
dc.subjectdiet therapy
dc.subjectinflammation
dc.subjectmetabolic syndrome X
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectrandomized controlled trial
dc.subjectC-Reactive Protein
dc.subjectDepression
dc.subjectDiet, Reducing
dc.subjectFemale
dc.subjectHumans
dc.subjectInflammation
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectMetabolic Syndrome X
dc.subjectMiddle Aged
dc.subjectWeight Loss
dc.titleA decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: A longitudinal study
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84900384800.pdf
Tamaño:
4.291Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem