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Tissue-engineering approaches in pancreatic islet transplantation

dc.contributor.authorPerez-Basterrechea M.
dc.contributor.authorEsteban M.M.
dc.contributor.authorVega J.A.
dc.contributor.authorObaya A.J.
dc.date.accessioned2020-09-02T22:25:46Z
dc.date.available2020-09-02T22:25:46Z
dc.date.issued2018
dc.identifier10.1002/bit.26821
dc.identifier.citation115, 12, 3009-3029
dc.identifier.issn00063592
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5775
dc.descriptionPancreatic islet transplantation is a promising alternative to whole-pancreas transplantation as a treatment of type 1 diabetes mellitus. This technique has been extensively developed during the past few years, with the main purpose of minimizing the complications arising from the standard protocols used in organ transplantation. By using a variety of strategies used in tissue engineering and regenerative medicine, pancreatic islets have been successfully introduced in host patients with different outcomes in terms of islet survival and functionality, as well as the desired normoglycemic control. Here, we describe and discuss those strategies to transplant islets together with different scaffolds, in combination with various cell types and diffusible factors, and always with the aim of reducing host immune response and achieving islet survival, regardless of the site of transplantation. © 2018 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.subjectbiomaterials
dc.subjectislet transplantation
dc.subjecttissue engineering
dc.subjecttype 1 diabetes
dc.subjectBiomaterials
dc.subjectTissue
dc.subjectTissue engineering
dc.subjectDiffusible factors
dc.subjectHost immune response
dc.subjectIslet transplantation
dc.subjectPancreas transplantation
dc.subjectPancreatic islet
dc.subjectStandard protocols
dc.subjectType 1 diabetes
dc.subjectType 1 diabetes mellitus
dc.subjectScaffolds (biology)
dc.subjectanimal
dc.subjecthuman
dc.subjectinsulin dependent diabetes mellitus
dc.subjectmouse
dc.subjectpancreas islet transplantation
dc.subjecttissue engineering
dc.subjecttissue scaffold
dc.subjectAnimals
dc.subjectDiabetes Mellitus, Type 1
dc.subjectHumans
dc.subjectIslets of Langerhans Transplantation
dc.subjectMice
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.titleTissue-engineering approaches in pancreatic islet transplantation
dc.typeReview


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