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In vitro modulation of Drimys winteri bark extract and the active compound polygodial on Salmo salar immune genes after exposure to Saprolegnia parasitica

dc.contributor.authorPereira-Torres D.
dc.contributor.authorGonçalves A.T.
dc.contributor.authorUlloa V.
dc.contributor.authorMartínez R.
dc.contributor.authorCarrasco H.
dc.contributor.authorOlea A.F.
dc.contributor.authorEspinoza L.
dc.contributor.authorGallardo-Escárate C.
dc.contributor.authorAstuya A.
dc.date.accessioned2020-09-02T22:25:45Z
dc.date.available2020-09-02T22:25:45Z
dc.date.issued2016
dc.identifier10.1016/j.fsi.2016.10.035
dc.identifier.citation59, , 103-108
dc.identifier.issn10504648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5771
dc.descriptionThe rapid development of the aquaculture industry has global concerns with health management and control strategies to prevent and/or treat diseases and increase sustainability standards. Saprolegniosis is a disease caused by Saprolegnia parasitica, and is characterized by promoting an immunosuppression in the host. This study evaluated in vitro the extract and one active compound (polygodial) of Drimys winteri, a Chilean medicinal tree as a potential early immunostimulatory aid in Saprolegniosis control. Atlantic salmon (Salmo salar) head kidney cells (ASK-1) were incubated with both extract and pure polygodial before exposure to S. parasitica mycelium, and the expression of the immune-related genes interleukin 1β (IL-1β), interferon α (IFNα), and major histocompatibility complex II (MHCII) was evaluated. Both evidenced immunomodulatory capacities by increasing gene expressions. This immunomodulation related to a mitigatory action counteracting the immunosuppressing effects of S. parasitica. Despite that most immune-related genes were up-regulated, the down-regulation of MHCII, characteristic of S. parasitica infection, was lessened by pre-incubation with the compounds. This study provides the first insight on the potential of D. winteri bark extract as a possible immunomodulatory and defensive strategy against this oomycete infection in fish. © 2016
dc.language.isoen
dc.publisherAcademic Press
dc.subjectD. winteri
dc.subjectGene expression
dc.subjectImmunostimulant
dc.subjectIn vitro
dc.subjectPolygodial
dc.subjectS. parasitica
dc.subjectSaprolegniosis
dc.subjectplant extract
dc.subjectpolygodial
dc.subjectsesquiterpene
dc.subjectanalysis
dc.subjectanimal
dc.subjectanimal food
dc.subjectbark
dc.subjectchemistry
dc.subjectdiet
dc.subjectDrimys
dc.subjectfish disease
dc.subjectimmunology
dc.subjectinfection
dc.subjectmicrobiology
dc.subjectphysiology
dc.subjectSalmo salar
dc.subjectSaprolegnia
dc.subjectveterinary
dc.subjectAnimal Feed
dc.subjectAnimals
dc.subjectDiet
dc.subjectDrimys
dc.subjectFish Diseases
dc.subjectInfection
dc.subjectPlant Bark
dc.subjectPlant Extracts
dc.subjectSalmo salar
dc.subjectSaprolegnia
dc.subjectSesquiterpenes
dc.titleIn vitro modulation of Drimys winteri bark extract and the active compound polygodial on Salmo salar immune genes after exposure to Saprolegnia parasitica
dc.typeArticle


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