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Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach

dc.contributor.authorPaquet M.
dc.contributor.authorCerasuolo J.O.
dc.contributor.authorThorburn V.
dc.contributor.authorFridman S.
dc.contributor.authorAlsubaie R.
dc.contributor.authorLopes R.D.
dc.contributor.authorCipriano L.E.
dc.contributor.authorSalamone P.
dc.contributor.authorMelling C.W.J.
dc.contributor.authorKhan A.R.
dc.contributor.authorSedeño L.
dc.contributor.authorFang J.
dc.contributor.authorDrangova M.
dc.contributor.authorMontero-Odasso M.
dc.contributor.authorMandzia J.
dc.contributor.authorKhaw A.V.
dc.contributor.authorRacosta J.M.
dc.contributor.authorPaturel J.
dc.contributor.authorSamoilov L.
dc.contributor.authorStirling D.
dc.contributor.authorBalint B.
dc.contributor.authorJaremek V.
dc.contributor.authorKoschinsky M.L.
dc.contributor.authorBoffa M.B.
dc.contributor.authorSummers K.
dc.contributor.authorIbañez A.
dc.contributor.authorMrkobrada M.
dc.contributor.authorSaposnik G.
dc.contributor.authorKimpinski K.
dc.contributor.authorWhitehead S.N.
dc.contributor.authorSposato L.A.
dc.date.accessioned2020-09-02T22:25:20Z
dc.date.available2020-09-02T22:25:20Z
dc.date.issued2018
dc.identifier10.1016/j.jstrokecerebrovasdis.2017.09.038
dc.identifier.citation27, 3, 606-619
dc.identifier.issn10523057
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5741
dc.descriptionBackground: It has been hypothesized that ischemic stroke can cause atrial fibrillation. By elucidating the mechanisms of neurogenically mediated paroxysmal atrial fibrillation, novel therapeutic strategies could be developed to prevent atrial fibrillation occurrence and perpetuation after stroke. This could result in fewer recurrent strokes and deaths, a reduction or delay in dementia onset, and in the lessening of the functional, structural, and metabolic consequences of atrial fibrillation on the heart. Methods: The Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE) study is an investigator-driven, translational, integrated, and transdisciplinary initiative. It comprises 3 complementary research streams that focus on atrial fibrillation detected after stroke: experimental, clinical, and epidemiological. The experimental stream will assess pre- and poststroke electrocardiographic, autonomic, anatomic (brain and heart pathology), and inflammatory trajectories in an animal model of selective insular cortex ischemic stroke. The clinical stream will prospectively investigate autonomic, inflammatory, and neurocognitive changes among patients diagnosed with atrial fibrillation detected after stroke by employing comprehensive and validated instruments. The epidemiological stream will focus on the demographics, clinical characteristics, and outcomes of atrial fibrillation detected after stroke at the population level by means of the Ontario Stroke Registry, a prospective clinical database that comprises over 23,000 patients with ischemic stroke. Conclusions: PARADISE is a translational research initiative comprising experimental, clinical, and epidemiological research aimed at characterizing clinical features, the pathophysiology, and outcomes of neurogenic atrial fibrillation detected after stroke. © 2018 National Stroke Association
dc.language.isoen
dc.publisherW.B. Saunders
dc.subjectatrial fibrillation
dc.subjectIschemic stroke
dc.subjectoutcome
dc.subjectpathophysiology
dc.subjectprognosis
dc.subjectrecurrence
dc.subjectC reactive protein
dc.subjectinterleukin 1beta
dc.subjectinterleukin 6
dc.subjecttumor necrosis factor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectatrial fibrillation
dc.subjectautonomic dysfunction
dc.subjectautonomic nervous system function
dc.subjectbrain damage
dc.subjectbrain ischemia
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectelectrocardiography
dc.subjectheart atrium flutter
dc.subjectheart left ventricle ejection fraction
dc.subjectheart rate
dc.subjecthuman
dc.subjectinsula
dc.subjectinterdisciplinary research
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectNational Institutes of Health Stroke Scale
dc.subjectneuroanatomy
dc.subjectneutrophil lymphocyte ratio
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance imaging
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectrat
dc.subjectrecurrent disease
dc.subjecttranslational research
dc.subjectambulatory electrocardiography
dc.subjectanimal
dc.subjectatrial fibrillation
dc.subjectbrain ischemia
dc.subjectcerebrovascular accident
dc.subjectcooperation
dc.subjectdisability
dc.subjectdisease model
dc.subjectfactual database
dc.subjectfemale
dc.subjectinterdisciplinary communication
dc.subjectmethodology
dc.subjectOntario
dc.subjectprocedures
dc.subjectprognosis
dc.subjectprospective study
dc.subjectregister
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectAnimals
dc.subjectAtrial Fibrillation
dc.subjectBrain Ischemia
dc.subjectCooperative Behavior
dc.subjectDatabases, Factual
dc.subjectDisability Evaluation
dc.subjectDisease Models, Animal
dc.subjectElectrocardiography, Ambulatory
dc.subjectFemale
dc.subjectHumans
dc.subjectInterdisciplinary Communication
dc.subjectMale
dc.subjectOntario
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectRegistries
dc.subjectResearch Design
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectStroke
dc.subjectTranslational Medical Research
dc.titlePathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach
dc.typeArticle


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