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In vivo stimulation of locus coeruleus: Effects on amygdala subnuclei

dc.contributor.authorOrtega E.R.
dc.contributor.authorCañadas F.
dc.contributor.authorCarvajal F.
dc.contributor.authorCardona D.
dc.date.accessioned2020-09-02T22:25:09Z
dc.date.available2020-09-02T22:25:09Z
dc.date.issued2017
dc.identifier10.21307/ane-2017-060
dc.identifier.citation77, 3, 261-268
dc.identifier.issn00651400
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5670
dc.descriptionThe locus coeruleus (LC) is the major noradrenergic nucleus and sends projections to almost all brain areas. A marked increase in norepinephrine release has been demonstrated in several brain areas in response to exposure to acute stressful stimuli, especially those innervated by LC projections. One of the brain areas innervated by LC neurons is the amygdala, a structure highly involved in emotional processes and memory formation. The aim of this study was to increase knowledge of the functional connectivity between the LC and the amygdala subnuclei. To reach this objective, we evaluated c-fos immunoreactive cells in amygdala nuclei following direct electrical stimulation of the LC in conscious animals. This analysis of c-fos immunoreactivity could inform whether there are differences in activity of the amygdala subnuclei related to LC electrical stimulation in conscious animals. Our results showed a marked increase in c-fos activity in these amygdala subnuclei both ipsilateral and contralateral to LC electrical stimulation in vivo. Therefore, our study provides evidence that in vivo electrical stimulation of LC is able to activate the amygdala subnuclei as measured by c-fos expression. © 2017 by Acta Neurobiologiae Experimentalis.
dc.language.isoen
dc.publisherNencki Institute of Experimental Biology
dc.subjectAmygdala subnuclei
dc.subjectC-Fos
dc.subjectLocus coeruleus
dc.subjectNoradrenergic system
dc.subjectprotein c fos
dc.subjectamygdala
dc.subjectanimal
dc.subjectcytology
dc.subjectelectrostimulation
dc.subjecthemispheric dominance
dc.subjectinjuries
dc.subjectlocus ceruleus
dc.subjectmale
dc.subjectmetabolism
dc.subjectnerve cell
dc.subjectnerve tract
dc.subjectphysiology
dc.subjectprocedures
dc.subjectrat
dc.subjectSprague Dawley rat
dc.subjectAmygdala
dc.subjectAnimals
dc.subjectElectric Stimulation
dc.subjectFunctional Laterality
dc.subjectLocus Coeruleus
dc.subjectMale
dc.subjectNeural Pathways
dc.subjectNeurons
dc.subjectProto-Oncogene Proteins c-fos
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.titleIn vivo stimulation of locus coeruleus: Effects on amygdala subnuclei
dc.typeArticle


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