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Prevalence of infection and antibiotic susceptibility of helicobacter pylori: An evaluation in public and private health systems of Southern Chile

dc.contributor.authorOporto M.
dc.contributor.authorPavez M.
dc.contributor.authorTroncoso C.
dc.contributor.authorCerda A.
dc.contributor.authorHofmann E.
dc.contributor.authorSierralta A.
dc.contributor.authorRios E.
dc.contributor.authorCoppelli L.
dc.contributor.authorBarrientos L.
dc.date.accessioned2020-09-02T22:24:49Z
dc.date.available2020-09-02T22:24:49Z
dc.date.issued2019
dc.identifier10.3390/pathogens8040226
dc.identifier.citation8, 4, -
dc.identifier.issn20760817
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5656
dc.descriptionHelicobacter pylori colonizes half of the human population. Age, ethnicity, and socioeconomic status are factors that influence the prevalence of the infection. This is important in southern Chile, one of the most unequal regions in the world, where a significant difference in the health access of the population occurs due to the existence of two competing health systems. Moreover, in the last few years, current protocols of H. pylori eradication have shown high rates of resistance with reduced therapeutic efficacy. This study reported the epidemiology of infection and attempted to identify divergent points among the population beneficiaries of the two health care schemes in southern Chile. Biopsies from public (n = 143) and private (n = 86) health systems were studied. At the same time, clinical and sociodemographic factors were evaluated. H. pylori strains were obtained from gastric biopsies for culture and molecular testing. Antibiotic susceptibility was determined by the agar dilution method. Differences about ethnicity, rural residence, and education (p ≤ 0.05) were observed between beneficiaries of the two health systems. The prevalence of H. pylori was 45%, with no significant differences regardless of the socioeconomic conditions. The only identified risk factor associated with H. pylori infection was Mapuche ethnicity (OR (odds ratio) = 2.30). H. pylori showed high resistance rates, particularly against clarithromycin (40%), levofloxacin (43.1%), and metronidazole (81.8%). This study highlighted the importance of Mapuche ancestry as a risk factor in southern Chile and emphasized the need to search for new eradication strategies as well as further studies evaluating therapeutic efficacy. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntibiotic resistance
dc.subjectPrevalence of Helicobacter pylori infection
dc.subjectPublic and private health systems
dc.subjectamoxicillin
dc.subjectclarithromycin
dc.subjectlevofloxacin
dc.subjectmetronidazole
dc.subjecttetracycline
dc.subjectagar dilution
dc.subjectantibiotic sensitivity
dc.subjectArticle
dc.subjectbacterial clearance
dc.subjectbacterial colonization
dc.subjectbacterial strain
dc.subjectbacterium culture
dc.subjectbacterium identification
dc.subjectbacterium isolation
dc.subjectChile
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectDNA extraction
dc.subjectdyspepsia
dc.subjectendoscopy
dc.subjectfemale
dc.subjecthealth care
dc.subjecthealth insurance
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmale
dc.subjectmeta analysis
dc.subjectminimum inhibitory concentration
dc.subjectmolecular biology
dc.subjectpolymerase chain reaction
dc.subjectprevalence
dc.subjectpublic health service
dc.subjectstomach biopsy
dc.titlePrevalence of infection and antibiotic susceptibility of helicobacter pylori: An evaluation in public and private health systems of Southern Chile
dc.typeArticle


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