Mostrar el registro sencillo del ítem

Biomass smoke as a risk factor for chronic obstructive pulmonary disease: Effects on innate immunity

dc.contributor.authorOlloquequi J.
dc.contributor.authorRafael Silva O.
dc.date.accessioned2020-09-02T22:24:48Z
dc.date.available2020-09-02T22:24:48Z
dc.date.issued2016
dc.identifier10.1177/1753425916650272
dc.identifier.citation22, 5, 373-381
dc.identifier.issn17534259
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5654
dc.descriptionChronic obstructive pulmonary disease (COPD), a major cause of mortality and morbidity worldwide, is considered an archetypical disease of innate immunity, where inhaled particles and gases trigger an inflammatory response, favoring tissue proliferation in small airways and tissue destruction in lung parenchyma, in addition to the recruitment of immune cells to these compartments. Although cigarette smoking is still considered the main risk factor for developing COPD, the trend of proposing biomass smoke (BS) exposure as a principal risk factor is gaining importance, as around 3 billion people worldwide are exposed to this pollutant daily. A considerable amount of evidence has shown the potential of BS as an enhancer of lung inflammation. However, an impairment of some innate immune responses after BS exposure has also been described. Regarding the mechanisms by which biomass smoke alters the innate immune responses, three main classes of cell surface receptors - the TLRs, the scavenger receptors and the transient receptor potential channels - have shown the ability to transduce signals initiated after BS exposure. This article is an updated and comprehensive review of the immunomodulatory effects described after the interaction of BS components with these receptors. © SAGE Publications.
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.subjectBiomass smoke
dc.subjectchronic obstructive pulmonary disease
dc.subjectinnate immunity
dc.subjectlung inflammation
dc.subjectToll-like receptors
dc.subjectscavenger receptor
dc.subjecttobacco smoke
dc.subjecttoll like receptor
dc.subjecttransient receptor potential channel
dc.subjectair pollutant
dc.subjectirritant agent
dc.subjectsmoke
dc.subjectbiomass
dc.subjectchemical composition
dc.subjectchronic obstructive lung disease
dc.subjectexposure
dc.subjecthost resistance
dc.subjecthuman
dc.subjectimmunomodulation
dc.subjectinnate immunity
dc.subjectparticulate matter
dc.subjectpneumonia
dc.subjectReview
dc.subjectrisk factor
dc.subjectsmoke
dc.subjecttoxicity
dc.subjectadverse effects
dc.subjectair pollutant
dc.subjectanimal
dc.subjectimmunology
dc.subjectinnate immunity
dc.subjectlung
dc.subjectpneumonia
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectsmoke
dc.subjectsmoking
dc.subjectAir Pollutants
dc.subjectAnimals
dc.subjectBiomass
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectIrritants
dc.subjectLung
dc.subjectPneumonia
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectRisk Factors
dc.subjectSmoke
dc.subjectSmoking
dc.titleBiomass smoke as a risk factor for chronic obstructive pulmonary disease: Effects on innate immunity
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84976872246.pdf
Tamaño:
3.332Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem