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Antifungal activity of eugenol derivatives against Botrytis cinerea

dc.contributor.authorOlea A.F.
dc.contributor.authorBravo A.
dc.contributor.authorMartínez R.
dc.contributor.authorThomas M.
dc.contributor.authorSedan C.
dc.contributor.authorEspinoza L.
dc.contributor.authorZambrano E.
dc.contributor.authorCarvajal D.
dc.contributor.authorSilva-Moreno E.
dc.contributor.authorCarrasco H.
dc.date.accessioned2020-09-02T22:24:45Z
dc.date.available2020-09-02T22:24:45Z
dc.date.issued2019
dc.identifier10.3390/molecules24071239
dc.identifier.citation24, 7, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5633
dc.descriptionBotrytis cinerea is a worldwide spread fungus that causes the grey mold disease, which is considered the most important factor in postharvest losses in fresh fruit crops. Consequently, the control of gray mold is a matter of current and relevant interest for agricultural industries. In this work, a series of phenylpropanoids derived from eugenol were synthesized and characterized. Their effects on the mycelial growth of a virulent and multi-resistant isolate of B. cinerea (PN2) have been evaluated and IC50 values for the most active compounds range between 31–95 ppm. The antifungal activity exhibited by these compounds is strongly related to their chemical structure, i.e., increasing activity has been obtained by isomerization of the double bond or introduction of a nitro group on the aromatic ring. Based on the relationship between the fungicide activities and chemical structure, a mechanism of action is proposed. Finally, the activity of these compounds is higher than that reported for the commercial fungicide BC-1000 that is currently employed to combat this disease. Thus, our results suggest that these compounds are potential candidates to be used in the design of new and effective control with inspired natural compounds of this pathogen. © 2019 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectBotrytis cinerea
dc.subjectChemical fungicides
dc.subjectEugenol
dc.subjectMycelial growth
dc.subjectReactive oxygen species
dc.subjectResistant isolate
dc.subjectantifungal agent
dc.subjecteugenol
dc.subjectfungicide
dc.subjectanalogs and derivatives
dc.subjectBotrytis
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectmicrobial sensitivity test
dc.subjectmicrobiology
dc.subjectphenotype
dc.subjectplant disease
dc.subjectAntifungal Agents
dc.subjectBotrytis
dc.subjectEugenol
dc.subjectFungicides, Industrial
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectPhenotype
dc.subjectPlant Diseases
dc.titleAntifungal activity of eugenol derivatives against Botrytis cinerea
dc.typeArticle


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