Mostrar el registro sencillo del ítem

Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol

dc.contributor.authorOlea A.F.
dc.contributor.authorAcevedo B.
dc.contributor.authorOssandon L.
dc.contributor.authorWorrall D.
dc.date.accessioned2020-09-02T22:24:45Z
dc.date.available2020-09-02T22:24:45Z
dc.date.issued2017
dc.identifier10.1016/j.colsurfa.2017.02.032
dc.identifier.citation526, , 1-7
dc.identifier.issn09277757
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5632
dc.descriptionHyperbranched polymers have been proposed as potential carriers or host compartments for controlled drug delivery. In this work the solubilization of alkylphenols into aggregates formed by hyperbranched polyglycidol HPG and its ester derivative has been studied. HPG17 was synthesized by ring-opening polymerization of glycidol, and then the ester HPG4-RBr13 has been obtained by reaction of hPG17 with 2-bromo isobutyryl bromide. The critical aggregate concentration CAC and micropolarity of aggregates were determined by using pyrene as fluorescence probe. CAC values obtained are 2.5 mM and 0.25 mM, for HPG17 and HPG4-RBr13, respectively. Our results indicate that the hydrophobic effect is larger for HPG4-RBr13, and that their aggregates are more hydrophobic, than for HPG17. In addition, their sizes and sizes distribution were determined by DLS. The partition of phenols between the micellar and aqueous phase was studied by using the pseudo-phase model, and the results show that the partition coefficients increases with increasing length of the side alkyl chain, and are larger for HPG4-RBr13 micelles than for HPG17 micelles. © 2017 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectFluorescence probing
dc.subjectHyperbranched polyglycidol
dc.subjectMultimolecular aggregates
dc.subjectp-Alkylphenols
dc.subjectPartition coefficients
dc.subjectAggregates
dc.subjectControlled drug delivery
dc.subjectDendrimers
dc.subjectEsters
dc.subjectFluorescence
dc.subjectHydrophobicity
dc.subjectMicelles
dc.subjectPhenols
dc.subjectSolubility
dc.subjectAlkylphenols
dc.subjectFluorescence probes
dc.subjectFluorescence probing
dc.subjectHydrophobic effect
dc.subjectHyperbranched polyglycidol
dc.subjectHyperbranched polymers
dc.subjectLow molecular weight
dc.subjectPartition coefficient
dc.subjectRing opening polymerization
dc.subjectalkylphenol
dc.subjectbromide
dc.subjectester derivative
dc.subjectfluorescent dye
dc.subjectglycidol
dc.subjecthyperbranched polyglycidol
dc.subjectphenol derivative
dc.subjectpolymer
dc.subjectunclassified drug
dc.subjectArticle
dc.subjectconcentration (parameters)
dc.subjectequilibrium constant
dc.subjectfluorescence imaging
dc.subjecthydrophobicity
dc.subjectmolecular weight
dc.subjectparticle size
dc.subjectpartition coefficient
dc.subjectphoton correlation spectroscopy
dc.subjectpriority journal
dc.subjectring opening metathesis polymerization
dc.subjectsolubilization
dc.subjectsynthesis
dc.titleSolubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85013128217.pdf
Tamaño:
3.267Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem