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Dynamics of Goldfish Subregional Hippocampal Pallium Activity throughout Spatial Memory Formation

dc.contributor.authorOcaña F.M.
dc.contributor.authorUceda S.
dc.contributor.authorArias J.L.
dc.contributor.authorSalas C.
dc.contributor.authorRodríguez F.
dc.date.accessioned2020-09-02T22:24:39Z
dc.date.available2020-09-02T22:24:39Z
dc.date.issued2017
dc.identifier10.1159/000478843
dc.identifier.citation90, 2, 154-170
dc.identifier.issn00068977
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5592
dc.descriptionThe teleost fish hippocampal pallium, like the hippocampus of tetrapods, is essential for relational map-like spatial memories. In mammals, these relational memories involve the dynamic interactions among different hippocampal subregions and between the hippocampus-neocortex network, which performs specialized operations such as memory encoding and retrieval. However, how the teleost hippocampal homologue operates to achieve comparably sophisticated spatial cognition capabilities is largely unknown. In the present study, the progressive changes in the metabolic activity of the pallial regions that have been proposed as possible homologues of the mammalian hippocampus were monitored in goldfish. Quantitative cytochrome oxidase histochemistry was used to measure the level of activation along the rostrocaudal axis of the ventral (Dlv) and dorsal parts of the dorsolateral division (Dld) and in the dorsoposterior division (Dp) of the goldfish telencephalic pallium throughout the time course of the learning process of a spatial memory task. The results revealed a significant increase in spatial memory-related metabolic activity in the Dlv, but not in the Dld, suggesting that the Dlv, but not the Dld, is comparable to the amniote hippocampus. Regarding the Dlv, the level of activation of the precommissural Dlv significantly increased at training onset but progressively declined to finally return to the basal pretraining level when the animals mastered the spatial task. In contrast, the commissural Dlv activation persisted even when the acquisition phase was completed and the animal's performance reached an asymptotic level. These results suggest that, like the dentate gyrus of mammals, the goldfish precommissural Dlv seems to respond nonlinearly to increments of change in sensory input, performing pattern separation under highly dissimilar input patterns. In addition, like the CA3 of mammals, the commissural Dlv likely operates in a continuum between two modes, a pattern separation or storage operation mode at early acquisition when the change in the sensory input is high, probably driven by the precommissural Dlv output, and a pattern completion or recall operation mode when the animals have mastered the task and the change in sensory input is small. Finally, an unexpected result of the present study is the persistent activation of the area Dp throughout the complete spatial task training period, which suggests that the Dp could be an important component of the pallial network involved in spatial memory in goldfish, and supports the hypothesis proposing that the Dp is a specialized part of the hippocampal pallium network. © 2017 S. Karger AG, Basel.
dc.language.isoen
dc.publisherS. Karger AG
dc.subjectCytochrome oxidase histochemistry
dc.subjectDentate gyrus/CA3 network
dc.subjectForebrain evolution
dc.subjectHippocampal neural network
dc.subjectHippocampal pallium
dc.subjectParahippocampal region
dc.subjectSpatial memory
dc.subjectTeleost fish
dc.subjectcytochrome c oxidase
dc.subjectanalysis of variance
dc.subjectanatomy and histology
dc.subjectanimal
dc.subjectcytology
dc.subjectdepth perception
dc.subjectgoldfish
dc.subjecthippocampus
dc.subjectmetabolism
dc.subjectneuropsychological test
dc.subjectphysiology
dc.subjectrandomization
dc.subjectspatial learning
dc.subjectspatial memory
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectElectron Transport Complex IV
dc.subjectGoldfish
dc.subjectHippocampus
dc.subjectNeuropsychological Tests
dc.subjectRandom Allocation
dc.subjectSpace Perception
dc.subjectSpatial Learning
dc.subjectSpatial Memory
dc.titleDynamics of Goldfish Subregional Hippocampal Pallium Activity throughout Spatial Memory Formation
dc.typeArticle


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