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Antimicrobial activities of diterpenoids and semisynthetic derivatives from Azorella compacta

dc.contributor.authorNúñez S.
dc.contributor.authorSan-Martín A.
dc.contributor.authorCorsini G.
dc.date.accessioned2020-09-02T22:24:38Z
dc.date.available2020-09-02T22:24:38Z
dc.date.issued2018
dc.identifier10.4067/S0717-97072018000404200
dc.identifier.citation63, 4, 4200-4204
dc.identifier.issn07179324
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5587
dc.descriptionThe antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus, Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5 and 8 have not been previously reported with the methods described in this research. The structures of all diterpenoids were elucidated by NMR 1H, 13C and IR spectroscopy. The natural diterpenoids, mulinolic ácid (1) and azorellanol (2) did not present antibacterial activity, but the six derivatives: 12-oxo-11,13-α,α-dihydroxymulin-20-oic ácid (3), 11-oxo-12,13-α,α-dihydroxymulin-20-oic ácid (4) 11,12-dioxo-13-α-hydroxymulin-20-oic ácid (5), 7-acetoxymulin-9,12-diene (6), mulin-9,12-dien-7-ol (7) and 7-acetoxy-12,13-dihydroxymulin-9-en (8) were active against three tested bacteria. The antibacterial activity reported for six semisynthetic diterpenoids may not be comparable with positive control ampicillin but demonstrate the possibility of modification of the biological activity of diterpenoids. © 2018 Sociedad Chilena de Quimica. All rights reserved.
dc.language.isoen
dc.publisherSociedad Chilena de Quimica
dc.subjectAntibacterial activity
dc.subjectApiaceae
dc.subjectAzorella compacta
dc.subjectDiterpenoids
dc.titleAntimicrobial activities of diterpenoids and semisynthetic derivatives from Azorella compacta
dc.typeArticle


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