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MUL+DO: A multicomponent index for the quick diagnosis of peritonitis in peritoneal dialysis patients [MUL+DO: índice multicomponente para el diagnóstico rápido de peritonitis en pacientes de diálisis peritoneal]

dc.contributor.authorNúñez Moral M.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorMéndez González A.
dc.contributor.authorRodríguez Suárez C.
dc.contributor.authorSánchez Álvarez J.E.
dc.date.accessioned2020-09-02T22:24:38Z
dc.date.available2020-09-02T22:24:38Z
dc.date.issued2018
dc.identifier10.1016/j.nefroe.2018.03.009
dc.identifier.citation38, 3, 273-278
dc.identifier.issn20132514
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5585
dc.descriptionPeritoneal infection is a common problem that has a negative impact on the survival of patients and the technique. The early administration of peritoneal infection treatment reduces complications. The goal of this study is to propose a multicomponent index (MUL+DO) for the quick and efficient diagnosis of peritoneal infection. We selected a training cohort of peritoneal effluent samples which were analyzed by Multistix ® 10 SG Siemens test strips for leukocyte detection. Then, each sample was examined according to the gold standard: number of leukocytes, polymorphonuclear percentage and microbiological culture. We constructed the MUL+DO index by adding one point to the MULTISTIX [0-1-2-3] modified chromatic scale if the patient reported pain. The MUL+DO index ranged from 0 to 4. A model validation cohort was then created. MUL+DO was applied to each sample and leukocytes and polymorphonuclear percentage were also assessed. The training cohort ultimately included 134 samples, 34 of which with infection (25.4% [17.6–33.1]). Samples with a MUL+DO value greater than 1 presented a sensitivity and specificity of 100%. The validation cohort included 100 samples with 16 infections (16% [8.3–23.7]). Assuming a sample with a MUL+DO value greater than 1 to be positive, we obtained a sensitivity of 100% and a specificity of 95.2%. The MUL+DO index applied to the training cohort showed a perfect separation of the positive and negative populations. All positive patients presented a score ≥2. In the validation cohort, the MUL+DO reported a sensitivity of 100% and a specificity of 95.2%. © 2017 Sociedad Española de Nefrología
dc.language.isoen
dc.language.isoes
dc.publisherElsevier Espana S.L.
dc.subjectDiagnosis
dc.subjectPeritoneal dialysis
dc.subjectPeritonitis
dc.subjectUrine test strip
dc.subjectadult
dc.subjectArticle
dc.subjectclinical article
dc.subjectclinical practice
dc.subjectcohort analysis
dc.subjectdiabetes mellitus
dc.subjectdiagnostic test
dc.subjectdiagnostic test accuracy study
dc.subjectdiagnostic value
dc.subjectfemale
dc.subjecthemodialysis patient
dc.subjecthuman
dc.subjecthuman cell
dc.subjectleukocyte count
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmulticomponent index
dc.subjectperitoneal dialysis
dc.subjectperitoneal fluid
dc.subjectperitonitis
dc.subjectself report
dc.subjectsensitivity and specificity
dc.subjectvalidation process
dc.subjectleukocyte
dc.subjectmicrobiology
dc.subjectperitonitis
dc.subjectstatistical model
dc.subjecttest strip
dc.subjecttime factor
dc.subjecthemodialysis fluid
dc.subjectFemale
dc.subjectHemodialysis Solutions
dc.subjectHumans
dc.subjectLeukocytes
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectModels, Statistical
dc.subjectPeritoneal Dialysis
dc.subjectPeritonitis
dc.subjectReagent Strips
dc.subjectTime Factors
dc.titleMUL+DO: A multicomponent index for the quick diagnosis of peritonitis in peritoneal dialysis patients [MUL+DO: índice multicomponente para el diagnóstico rápido de peritonitis en pacientes de diálisis peritoneal]
dc.typeArticle


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