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Anxiolytic-like effects of 7H-benzo[e]perimidin-7-one derivatives through elevated plus-maze test in mice

dc.contributor.authorNuñez J.
dc.contributor.authorFontenla J.A.
dc.contributor.authorNabavi S.M.
dc.contributor.authorUriarte E.
dc.contributor.authorHerrera A.
dc.contributor.authorSobarzo-Sánchez E.
dc.date.accessioned2020-09-02T22:24:37Z
dc.date.available2020-09-02T22:24:37Z
dc.date.issued2015
dc.identifier10.2174/1568026615666150427125535
dc.identifier.citation15, 17, 1750-1754
dc.identifier.issn15680266
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5578
dc.descriptionAnxiety is one of the behavior disorders that has been studied more together with depression in the world, and that has enormous interference in the mental health of the affected patients. The states of panic and phobia are a part of the psychological characteristics that some drugs have tried to control though with varied side effects that are proven to be difficult to control. The use of perimidinone derivatives against the effects of anxiety has generated that A5 is the most active and selective anxiolytic compound, differing with regard to diazepam (DZP) used as control reference in elevated plus-maze (EPM) test. This test allows to conclude that it is feasible to differentiate the use selective as anxiolytic or antidepressant of certain perimidinones, because A4 had been characterized by our research group as an important antidepressant respect to A5 studied in previous reports. © 2015, Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subject7H-benzo[e]perimidin-7-one
dc.subjectAnxiety
dc.subjectDepression
dc.subjectOxoisoaporphines
dc.subjectPerimidinones
dc.subjectPlus-maze test
dc.subject7h benzo(e)perimidin 7 one derivative
dc.subjectantidepressant agent
dc.subjectanxiolytic agent
dc.subjectdiazepam
dc.subjectpentetrazole
dc.subjectunclassified drug
dc.subjectalkaloid
dc.subjectanxiolytic agent
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantidepressant activity
dc.subjectanxiety disorder
dc.subjectArticle
dc.subjectbehavior disorder
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectelevated plus maze test
dc.subjectforced swim test
dc.subjectmale
dc.subjectmental health
dc.subjectmouse
dc.subjectmovement (physiology)
dc.subjectnonhuman
dc.subjectphobia
dc.subjecttranquilizing activity
dc.subjectvelocity
dc.subjectanimal
dc.subjectanimal behavior
dc.subjectanxiety
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectdrug therapy
dc.subjectmaze test
dc.subjectAlkaloids
dc.subjectAnimals
dc.subjectAnti-Anxiety Agents
dc.subjectAnxiety
dc.subjectBehavior, Animal
dc.subjectMaze Learning
dc.subjectMice
dc.subjectMolecular Structure
dc.titleAnxiolytic-like effects of 7H-benzo[e]perimidin-7-one derivatives through elevated plus-maze test in mice
dc.typeArticle


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