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Securinine derivatives as potential anti-amyloid therapeutic approach

dc.contributor.authorNeganova M.E.
dc.contributor.authorKlochkov S.G.
dc.contributor.authorPetrova L.N.
dc.contributor.authorShevtsova E.F.
dc.contributor.authorAfanasieva S.V.
dc.contributor.authorChudinova E.S.
dc.contributor.authorFisenko V.P.
dc.contributor.authorBachurin S.O.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:24:17Z
dc.date.available2020-09-02T22:24:17Z
dc.date.issued2017
dc.identifier10.2174/1871527315666161107090525
dc.identifier.citation16, 3, 351-355
dc.identifier.issn18715273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5564
dc.descriptionBackground: Oxidative stress and amyloid deposition are tightly interconnected pathological features of Alzheimer disease. In this respect, both amyloid production and aggregation may be stimulated by oxidative stress and also the increase of pathogenic β-amyloid and its aggregated form lead to oxidative stress progression. Therefore, the search for potential drugs with both antioxidant and antiaggregation properties are of great interest. Methods: In this study, we described the stereospecific synthesis of alkaloid securinine aminoderivatives. Results: We showed that the newly synthesized compounds possess antioxidant and metal-chelating properties. Indeed, we report that one compound has inhibitory effects towards β-amyloid aggregation. Conclusion: Based on these results, aminoderivatives of securinine scaffold are promising compounds for development of new drugs for the treatment of neurodegenerative diseases. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAlkaloids
dc.subjectAntioxidant
dc.subjectLipid peroxidation
dc.subjectNeurodegenerative diseases
dc.subjectNeuroprotection
dc.subjectSecurinine
dc.subjectβ-amyloid
dc.subjectamyloid beta protein
dc.subjectantioxidant
dc.subjectsecurinine
dc.subjectamyloid beta protein
dc.subjectamyloid beta-protein (1-42)
dc.subjectantioxidant
dc.subjectazepine derivative
dc.subjectfused heterocyclic rings
dc.subjectlactone
dc.subjectpeptide fragment
dc.subjectpiperidine derivative
dc.subjectsecurinine
dc.subjectanimal experiment
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectdegenerative disease
dc.subjectfluorescence analysis
dc.subjecthigh performance liquid chromatography
dc.subjectIC50
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectoxidative stress
dc.subjectrat
dc.subjectAlzheimer disease
dc.subjectamyloidosis
dc.subjectanimal
dc.subjectchemistry
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectAlzheimer Disease
dc.subjectAmyloid beta-Peptides
dc.subjectAmyloidosis
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectAzepines
dc.subjectHeterocyclic Compounds, Bridged-Ring
dc.subjectHumans
dc.subjectLactones
dc.subjectMale
dc.subjectOxidative Stress
dc.subjectPeptide Fragments
dc.subjectPiperidines
dc.subjectRats
dc.titleSecurinine derivatives as potential anti-amyloid therapeutic approach
dc.typeArticle


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