Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide
Autor
Nardocci G.
Martin A.
Abarzúa S.
Rodríguez J.
Simon F.
Reyes E.P.
Acuña-Castillo C.
Navarro C.
Cortes P.P.
Fernández R.
Resumen
Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis. © 2014 Elsevier B.V.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats (2020)
Del Rio R.; Andrade D.C.; Lucero C.; Arias P.; Iturriaga R. (Lippincott Williams and Wilkins, 2016) -
Article
Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia (2020)
Morgan B.J.; Bates M.L.; Rio R.D.; Wang Z.; Dopp J.M. (Elsevier B.V., 2016) -
Article
Lipopolysaccharide-Induced Ionized Hypocalcemia and Acute Kidney Injury in Carotid Chemo/Baro-Denervated Rats (2020)
Fernández R.; Cortés P.; del Rio R.; Acuña-Castillo C.; Reyes E.P.; Reyes E.P. (Springer New York LLC, 2015)