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Behavioral effects of 2,3-dihydro- and oxoisoaporphine derivatives in post stroke-depressive like behavior in male balb/c mice

dc.contributor.authorNabavi S.F.
dc.contributor.authorSobarzo-Sánchez E.
dc.contributor.authorNabavi S.M.
dc.contributor.authorDaglia M.
dc.contributor.authorMoghaddam A.H.
dc.contributor.authorSilva A.G.
dc.date.accessioned2020-09-02T22:24:12Z
dc.date.available2020-09-02T22:24:12Z
dc.date.issued2013
dc.identifier10.2174/15680266113139990148
dc.identifier.citation13, 17, 2127-2133
dc.identifier.issn15680266
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5540
dc.descriptionIn this study, antidepressant-like effects of intra-cerebroventricularly administration of oxoisoaporphine derivatives in post stroke-depressive like behavior were examined through despair swimming and tail suspension models. For this aim, acute ischemic stroke was induced by bilateral common carotid arteries occlusion which significantly changed the normal behaviors of male balb/c mice. We performed stroke-induced anhedonia test as a key result of post strokedepressive like behavior by determination of sucrose consumption. Results show that some 2,3-dihydro- and oxoisoaporphine derivatives modified the abnormality in the behaviors through decreasing in the immobility time in tail suspension and despair swimming models and increasing in the swimming and climbing times in despair swimming model. We concluded that these alkaloids showed antidepressant actions and therefore can be used for treatment of post strokedepressive like behavior in acute ischemic stroke patients. © 2013 Bentham Science Publishers.
dc.language.isoen
dc.subjectAcute ischemic stroke
dc.subjectAntidepressant
dc.subjectDepressive-like behavior
dc.subjectOxoisoaporphine
dc.subject2,3 dihydro 7h dibenzo[de,h]quinoline 7 one
dc.subjectaporphine derivative
dc.subjectoxoisoaporphine derivative
dc.subjectsucrose
dc.subjectunclassified drug
dc.subjectanhedonia
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantidepressant activity
dc.subjectarticle
dc.subjectbrain ischemia
dc.subjectcarotid artery obstruction
dc.subjectchromatography
dc.subjectclimbing
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdespair swimming test
dc.subjectdrug synthesis
dc.subjectimmobility
dc.subjectmale
dc.subjectmeta analysis (topic)
dc.subjectmouse
dc.subjectnonhuman
dc.subjectopen field test
dc.subjectpost stroke depression
dc.subjectrearing
dc.subjecttail suspension test
dc.subjectAnhedonia
dc.subjectAnimals
dc.subjectAntidepressive Agents
dc.subjectAporphines
dc.subjectBehavior, Animal
dc.subjectDepression
dc.subjectDisease Models, Animal
dc.subjectHindlimb Suspension
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectStroke
dc.subjectSwimming
dc.titleBehavioral effects of 2,3-dihydro- and oxoisoaporphine derivatives in post stroke-depressive like behavior in male balb/c mice
dc.typeArticle


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