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Genistein: A boon for mitigating ischemic stroke

dc.contributor.authorNabavi S.F.
dc.contributor.authorDaglia M.
dc.contributor.authorTundis R.
dc.contributor.authorLoizzo M.R.
dc.contributor.authorSobarzo-Sánchez E.
dc.contributor.authorOrhan I.E.
dc.contributor.authorNabavi S.M.
dc.date.accessioned2020-09-02T22:24:12Z
dc.date.available2020-09-02T22:24:12Z
dc.date.issued2015
dc.identifier10.2174/1568026615666150427122709
dc.identifier.citation15, 17, 1714-1721
dc.identifier.issn15680266
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5539
dc.descriptionIn last decades, diet and dietary components have been regarded as important strategies to prevent the development or mitigate numerous chronic diseases, including inflammation, cardiovascular pathologies, cancer, etc. One of the most common dietary components of Asian population is soy. A plethora of research shows the promising effect of soy soy-based foodstuffs and genistein, which is one of the predominant isoflavone compounds, in the prevention and mitigation of stroke. Growing evidence shows that genistein, which is a selective estrogen receptor modulator, mitigates ischemic stroke-induced damages through the modification of oxidative stress and molecular pathways. The promising pharmacological role of genistein is attributed to its ability to suppress nuclear factor (NF)-kappa B and Akt signaling pathway, direct antioxidant action, and targeting estrogen and androgen-mediated molecular pathways which help to mitigate stroke damages and prolong cell survival. In this work, we systematically review the current reports on the therapeutic role of genistein against ischemic stroke and its molecular mechanism of actions. © 2015, Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectGenistein
dc.subjectIsoflavone
dc.subjectOxidative stress
dc.subjectSignal transduction
dc.subjectgenistein
dc.subjectisoflavone
dc.subjectgenistein
dc.subjectprotein kinase inhibitor
dc.subjectArticle
dc.subjectatherosclerosis
dc.subjectblood vessel occlusion
dc.subjectbrain ischemia
dc.subjectchemical structure
dc.subjectdisease severity
dc.subjectdrug bioavailability
dc.subjecthuman
dc.subjecthypertension
dc.subjectoxidative stress
dc.subjectprotein phosphorylation
dc.subjectsignal transduction
dc.subjectanimal
dc.subjectbrain ischemia
dc.subjectchemistry
dc.subjectStroke
dc.subjectstructure activity relation
dc.subjectAnimals
dc.subjectBrain Ischemia
dc.subjectGenistein
dc.subjectHumans
dc.subjectMolecular Structure
dc.subjectProtein Kinase Inhibitors
dc.subjectStroke
dc.subjectStructure-Activity Relationship
dc.titleGenistein: A boon for mitigating ischemic stroke
dc.typeArticle


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