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Development of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes: Synthesis and biological activity evaluations

dc.contributor.authorMurcia R.A.
dc.contributor.authorLeal S.M.
dc.contributor.authorRoa M.V.
dc.contributor.authorNagles E.
dc.contributor.authorMuñoz-Castro A.
dc.contributor.authorHurtado J.J.
dc.date.accessioned2020-09-02T22:24:06Z
dc.date.available2020-09-02T22:24:06Z
dc.date.issued2018
dc.identifier10.3390/molecules23082013
dc.identifier.citation23, 8, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5493
dc.descriptionIn this work, six complexes (2-7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3-7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL-1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities. © 2018 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntibacterial activity
dc.subjectAntifungal activity
dc.subjectCobalt(II) and chromium(III) complexes
dc.subjectTriazole ligands
dc.subjectantifungal agent
dc.subjectantiinfective agent
dc.subjectchromium
dc.subjectcobalt
dc.subjectligand
dc.subjecttriazole derivative
dc.subjectbacterium
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectfungus
dc.subjectinfrared spectroscopy
dc.subjectmicrobial sensitivity test
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectstructure activity relation
dc.subjectsynthesis
dc.subjectAnti-Bacterial Agents
dc.subjectAntifungal Agents
dc.subjectBacteria
dc.subjectChromium
dc.subjectCobalt
dc.subjectFungi
dc.subjectLigands
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.subjectStructure-Activity Relationship
dc.subjectTriazoles
dc.titleDevelopment of antibacterial and antifungal triazole chromium(III) and cobalt(II) complexes: Synthesis and biological activity evaluations
dc.typeArticle


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