Mostrar el registro sencillo del ítem

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

dc.contributor.authorMunguía-Calzada P.
dc.contributor.authorFernández-Vega I.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorDíaz-Coto S.
dc.contributor.authorGarcía-Pedrero J.M.
dc.contributor.authorVivanco B.
dc.contributor.authorOsuna C.G.
dc.contributor.authorVazquez-Lopez F.
dc.contributor.authorRodrigo J.P.
dc.contributor.authorSantos-Juanes J.
dc.date.accessioned2020-09-02T22:23:45Z
dc.date.available2020-09-02T22:23:45Z
dc.date.issued2019
dc.identifier10.1002/hed.25556
dc.identifier.citation41, 5, 1290-1296
dc.identifier.issn10433074
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5468
dc.descriptionBackground: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC). Objective: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Methods: FAK and cortactin expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data. Results: FAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08-3.86], [P = 0.029]) and 2.23 (95% CI [1.01-4.91], [P = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis. Conclusion: These findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC. © 2018 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.subjectcortactin
dc.subjectcutaneous squamous cell carcinoma
dc.subjectfocal adhesion kinase
dc.subjectnodal metastasis
dc.subjectprognosis
dc.subjectcortactin
dc.subjectfocal adhesion kinase
dc.subjectaged
dc.subjectArticle
dc.subjectcancer prognosis
dc.subjectcancer size
dc.subjectcancer staging
dc.subjectcancer surgery
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthead and neck squamous cell carcinoma
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetastasis free survival
dc.subjectoverall survival
dc.subjectperineural invasion
dc.subjectprimary tumor
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectskin carcinoma
dc.subjectsurvival rate
dc.subjecttissue microarray
dc.titleCorrelation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85058191899.pdf
Tamaño:
3.167Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem