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Neuroprotection in hypoxic-ischemic brain injury targeting glial cells

dc.contributor.authorMucci S.
dc.contributor.authorHerrera M.I.
dc.contributor.authorBarreto G.E.
dc.contributor.authorKolliker-Frers R.
dc.contributor.authorCapani F.
dc.date.accessioned2020-09-02T22:23:44Z
dc.date.available2020-09-02T22:23:44Z
dc.date.issued2017
dc.identifier10.2174/1381612823666170727145422
dc.identifier.citation23, 26, 3899-3906
dc.identifier.issn13816128
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5463
dc.descriptionBrain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectBrain injury
dc.subjectGlial cells
dc.subjectHypoxia-ischemia
dc.subjectNeuroprotection
dc.subjectPharmacological treatments
dc.subjectAMPA receptor
dc.subjectAMPA receptor antagonist
dc.subjectapocynin
dc.subjectbungarotoxin receptor
dc.subjectcannabinoid 2 receptor agonist
dc.subjectcarnosine
dc.subjectcatalpol
dc.subjectcholinergic receptor stimulating agent
dc.subjectcynarine
dc.subjectdeferoxamine
dc.subjectdiclofenac
dc.subjectenkephalin
dc.subjectephrin A3
dc.subjectephrin receptor A4
dc.subjectfingolimod
dc.subjectginsenoside Rb 1
dc.subjectglutamic acid
dc.subjecthypophysis adenylate cyclase activating polypeptide
dc.subjectinterleukin 4
dc.subjectkainic acid receptor antagonist
dc.subjectmercaptamine
dc.subjectmicroRNA
dc.subjectmicroRNA 181
dc.subjectneuroprotective agent
dc.subjecto 1966
dc.subjectpropofol
dc.subjectsmall interfering RNA
dc.subjectsphingosine kinase 1
dc.subjectsulforedoxin
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectneuroprotective agent
dc.subjectastrocyte
dc.subjectcellular immunity
dc.subjectdrug conjugation
dc.subjectdrug design
dc.subjectdrug mechanism
dc.subjectdrug targeting
dc.subjectgene expression
dc.subjectgene expression regulation
dc.subjectglia cell
dc.subjecthuman
dc.subjecthypothermia
dc.subjecthypoxic ischemic encephalopathy
dc.subjectmicroglia
dc.subjectmolecularly targeted therapy
dc.subjectneuromodulation
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectreceptor blocking
dc.subjectReview
dc.subjectstem cell
dc.subjectanimal
dc.subjectdrug delivery system
dc.subjectdrug effect
dc.subjectglia
dc.subjecthypoxic ischemic encephalopathy
dc.subjectmetabolism
dc.subjectnerve cell
dc.subjectneuroprotection
dc.subjectpathology
dc.subjectphysiology
dc.subjecttrends
dc.subjectAnimals
dc.subjectDrug Delivery Systems
dc.subjectHumans
dc.subjectHypoxia-Ischemia, Brain
dc.subjectNeuroglia
dc.subjectNeurons
dc.subjectNeuroprotection
dc.subjectNeuroprotective Agents
dc.titleNeuroprotection in hypoxic-ischemic brain injury targeting glial cells
dc.typeReview


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