Mostrar el registro sencillo del ítem

Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation

dc.contributor.authorMoya E.A.
dc.contributor.authorArias P.
dc.contributor.authorVarela C.
dc.contributor.authorOyarce M.P.
dc.contributor.authorDel Rio R.
dc.contributor.authorIturriaga R.
dc.date.accessioned2020-09-02T22:23:44Z
dc.date.available2020-09-02T22:23:44Z
dc.date.issued2016
dc.identifier10.1155/2016/9802136
dc.identifier.citation2016, , -
dc.identifier.issn19420900
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5462
dc.descriptionOxidative stress is involved in the development of carotid body (CB) chemosensory potentiation and systemic hypertension induced by chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea. We tested whether peroxynitrite (ONOO-), a highly reactive nitrogen species, is involved in the enhanced CB oxygen chemosensitivity and the hypertension during CIH. Accordingly, we studied effects of Ebselen, an ONOO- scavenger, on 3-nitrotyrosine immunoreactivity (3-NT-ir) in the CB, the CB chemosensory discharge, and arterial blood pressure (BP) in rats exposed to CIH. Male Sprague-Dawley rats were exposed to CIH (5% O2, 12 times/h, 8 h/day) for 7 days. Ebselen (10 mg/kg/day) was administrated using osmotic minipumps and BP measured with radiotelemetry. Compared to the sham animals, CIH-treated rats showed increased 3-NT-ir within the CB, enhanced CB chemosensory responses to hypoxia, increased BP response to acute hypoxia, and hypertension. Rats treated with Ebselen and exposed to CIH displayed a significant reduction in 3-NT-ir levels (60.8 ± 14.9 versus 22.9 ± 4.2 a.u.), reduced CB chemosensory response to 5% O2 (266.5 ± 13.4 versus 168.6 ± 16.8 Hz), and decreased mean BP (116.9 ± 13.2 versus 82.1 ± 5.1 mmHg). Our results suggest that CIH-induced CB chemosensory potentiation and hypertension are critically dependent on ONOO- formation. © 2016 Esteban A. Moya et al.
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.titleIntermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84954286574.pdf
Tamaño:
2.311Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem