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Influence of inflammation in the process of T lymphocyte differentiation: Proliferative, metabolic, and oxidative changes
dc.contributor.author | Moro-García M.A. | |
dc.contributor.author | Mayo J.C. | |
dc.contributor.author | Sainz R.M. | |
dc.contributor.author | Alonso-Arias R. | |
dc.date.accessioned | 2020-09-02T22:23:42Z | |
dc.date.available | 2020-09-02T22:23:42Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.3389/fimmu.2018.00339 | |
dc.identifier.citation | 9, MAR, - | |
dc.identifier.issn | 16643224 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/5455 | |
dc.description | T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last stages of their differentiation, in a replicative state of senescence, go through a series of phases. In several of these stages, T lymphocytes are subjected to exponential growth in successive encounters with the same antigen. This entire process occurs throughout the life of a human individual and, earlier, in patients with chronic infections/pathologies through inflammatory mediators, first acutely and later in a chronic form. This process plays a fundamental role in amplifying the activating signals on T lymphocytes and directing their clonal proliferation. The mechanisms that control cell growth are high levels of telomerase activity and maintenance of telomeric length that are far superior to other cell types, as well as metabolic adaptation and redox control. Large numbers of highly differentiated memory cells are accumulated in the immunological niches where they will contribute in a significant way to increase the levels of inflammatory mediators that will perpetuate the new state at the systemic level. These levels of inflammation greatly influence the process of T lymphocyte differentiation from naïve T lymphocyte, even before, until the arrival of exhaustion or cell death. The changes observed during lymphocyte differentiation are correlated with changes in cellular metabolism and these in turn are influenced by the inflammatory state of the environment where the cell is located. Reactive oxygen species (ROS) exert a dual action in the population of T lymphocytes. Exposure to high levels of ROS decreases the capacity of activation and T lymphocyte proliferation; however, intermediate levels of oxidation are necessary for the lymphocyte activation, differentiation, and effector functions. In conclusion, we can affirm that the inflammatory levels in the environment greatly influence the differentiation and activity of T lymphocyte populations. However, little is known about the mechanisms involved in these processes. The elucidation of these mechanisms would be of great help in the advance of improvements in pathologies with a large inflammatory base such as rheumatoid arthritis, intestinal inflammatory diseases, several infectious diseases and even, cancerous processes. © 2018 Moro-García, Mayo, Sainz and Alonso-Arias. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.subject | Differentiation | |
dc.subject | Exhaustion | |
dc.subject | Inflammation | |
dc.subject | Metabolic reprogramming | |
dc.subject | Redox balance | |
dc.subject | T lymphocytes | |
dc.subject | adenosine triphosphate | |
dc.subject | catalase | |
dc.subject | CD27 antigen | |
dc.subject | CD28 antigen | |
dc.subject | gamma interferon | |
dc.subject | glucose transporter | |
dc.subject | granulocyte macrophage colony stimulating factor | |
dc.subject | interleukin 12 | |
dc.subject | interleukin 15 | |
dc.subject | interleukin 1beta | |
dc.subject | interleukin 2 receptor beta | |
dc.subject | interleukin 6 | |
dc.subject | peroxidase | |
dc.subject | pyruvate dehydrogenase kinase | |
dc.subject | reactive oxygen metabolite | |
dc.subject | superoxide dismutase | |
dc.subject | telomerase | |
dc.subject | thioredoxin | |
dc.subject | transcription factor T bet | |
dc.subject | tumor necrosis factor | |
dc.subject | aerobic glycolysis | |
dc.subject | cell death | |
dc.subject | cell growth | |
dc.subject | cell proliferation | |
dc.subject | human | |
dc.subject | infection | |
dc.subject | inflammation | |
dc.subject | lymphocyte differentiation | |
dc.subject | memory cell | |
dc.subject | metabolism | |
dc.subject | mitophagy | |
dc.subject | oxidation | |
dc.subject | oxidative stress | |
dc.subject | pentose phosphate cycle | |
dc.subject | Review | |
dc.subject | T lymphocyte | |
dc.subject | tumor growth | |
dc.subject | tumor microenvironment | |
dc.title | Influence of inflammation in the process of T lymphocyte differentiation: Proliferative, metabolic, and oxidative changes | |
dc.type | Review |