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Theoretical and experimental approaches aimed at drug design targeting neurodegenerative diseases

dc.contributor.authorMorales-Navarro S.
dc.contributor.authorPrent-Peñaloza L.
dc.contributor.authorNúñez Y.A.R.
dc.contributor.authorSánchez-Aros L.
dc.contributor.authorForero-Doria O.
dc.contributor.authorGonzález W.
dc.contributor.authorCampilllo N.E.
dc.contributor.authorReyes-Parada M.
dc.contributor.authorMartínez A.
dc.contributor.authorRamírez D.
dc.date.accessioned2020-09-02T22:23:38Z
dc.date.available2020-09-02T22:23:38Z
dc.date.issued2019
dc.identifier10.3390/PR7120940
dc.identifier.citation7, 12, -
dc.identifier.issn22279717
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5434
dc.descriptionIn recent years, green chemistry has been strengthening, showing how basic and applied sciences advance globally, protecting the environment and human health. A clear example of this evolution is the synergy that now exists between theoretical and computational methods to design new drugs in the most efficient possible way, using the minimum of reagents and obtaining the maximum yield. The development of compounds with potential therapeutic activity against multiple targets associated with neurodegenerative diseases/disorders (NDD) such as Alzheimer's disease is a hot topic in medical chemistry, where different scientists from various disciplines collaborate to find safe, active, and effective drugs. NDD are a public health problem, affecting mainly the population over 60 years old. To generate significant progress in the pharmacological treatment of NDD, it is necessary to employ different experimental strategies of green chemistry, medical chemistry, and molecular biology, coupled with computational and theoretical approaches such as molecular simulations and chemoinformatics, all framed in the rational drug design targeting NDD. Here, we review how green chemistry and computational approaches have been used to develop new compounds with the potential application against NDD, as well as the challenges and new directions of the drug development multidisciplinary process. © 2019 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectChemoinformatics
dc.subjectDrug design
dc.subjectGreen chemistry
dc.subjectMedical chemistry
dc.subjectMolecular modeling
dc.subjectNeurodegenerative diseases
dc.titleTheoretical and experimental approaches aimed at drug design targeting neurodegenerative diseases
dc.typeReview


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