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Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

dc.contributor.authorMontenegro I.
dc.contributor.authorTomasoni G.
dc.contributor.authorBosio C.
dc.contributor.authorQuiñones N.
dc.contributor.authorMadrid A.
dc.contributor.authorCarrasco H.
dc.contributor.authorOlea A.
dc.contributor.authorMartinez R.
dc.contributor.authorCuellar M.
dc.contributor.authorVillena J.
dc.date.accessioned2020-09-02T22:23:32Z
dc.date.available2020-09-02T22:23:32Z
dc.date.issued2014
dc.identifier10.3390/molecules191118993
dc.identifier.citation19, 11, 18993-19006
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5392
dc.descriptionTwelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectApoptosis
dc.subjectCancer cell lines
dc.subjectCaspasa-3 activity
dc.subjectCytotoxic activity
dc.subjectDrimanes
dc.subjectMitochondrial membrane permeability
dc.subjectNordrimanes
dc.subjectSesquiterpenes
dc.subjectconfertifolin
dc.subjectdrimane
dc.subjectdrimenol
dc.subjectfuran derivative
dc.subjectpolygodial
dc.subjectsesquiterpene
dc.subjectterpene
dc.subjecttetralin derivative
dc.subjectcell membrane permeability
dc.subjectdrug effects
dc.subjectHT 29 cell line
dc.subjecthuman
dc.subjectIC50
dc.subjectMCF 7 cell line
dc.subjectmitochondrial membrane
dc.subjectNeoplasms
dc.subjecttumor cell line
dc.subjectCell Line, Tumor
dc.subjectCell Membrane Permeability
dc.subjectFurans
dc.subjectHT29 Cells
dc.subjectHumans
dc.subjectInhibitory Concentration 50
dc.subjectMCF-7 Cells
dc.subjectMitochondrial Membranes
dc.subjectNeoplasms
dc.subjectSesquiterpenes
dc.subjectTerpenes
dc.subjectTetrahydronaphthalenes
dc.titleStudy on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
dc.typeArticle


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