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Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations

dc.contributor.authorMolina S.J.
dc.contributor.authorBuján G.E.
dc.contributor.authorRodriguez Gonzalez M.
dc.contributor.authorCapani F.
dc.contributor.authorGómez-Casati M.E.
dc.contributor.authorGuelman L.R.
dc.date.accessioned2020-09-02T22:23:31Z
dc.date.available2020-09-02T22:23:31Z
dc.date.issued2019
dc.identifier10.3389/fnbeh.2019.00182
dc.identifier.citation13, , -
dc.identifier.issn16625153
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5382
dc.descriptionExposure of developing rats to noise has shown to induce hippocampal-related behavioral alterations that were prevented after a week of housing in an enriched environment. However, neither the effect of repeated exposures nor its impact on key endogenous antioxidants had been studied yet. Thus, the aim of the present work was to reveal novel data about hippocampal oxidative state through the measurement of possible age-related differences in the levels of hippocampal thioredoxins in rats exposed to noise at different developmental ages and subjected to different schemes and housing conditions. In addition, the possibility that oxidative changes could underlie hippocampal-related behavioral changes was also analyzed. Developing male Wistar rats were exposed to noise for 2 h, either once or for 5 days. Upon weaning, some animals were transferred to an enriched cage for 1 week, whereas others were kept in standard cages. One week later, auditory and behavioral assessments, as well as measurement of hippocampal thioredoxin, were performed. Whereas no changes in the auditory function were observed, significant behavioral differences were found, that varied according to the age, scheme of exposure and housing condition. In addition, a significant increase in Trx-1 levels was found in all noise-exposed groups housed in standard cages. Housing animals in an enriched environment for 1 week was effective in preventing most of these changes. These findings suggest that animals become less susceptible to undergo behavioral alterations after repeated exposure to an environmental challenge, probably due to the ability of adaptation to an unfavorable condition. Moreover, it could be hypothesized that damage to younger individuals could be more easily prevented by a housing manipulation. © Copyright © 2019 Molina, Buján, Rodriguez Gonzalez, Capani, Gómez-Casati and Guelman.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectbehavior
dc.subjectenriched environment
dc.subjecthippocampus
dc.subjectnoise
dc.subjectthioredoxin
dc.subjectthioredoxin
dc.subjectthioredoxin 1
dc.subjectthioredoxin 2
dc.subjectaerobic metabolism
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectbehavior assessment
dc.subjectbehavior change
dc.subjectcontrolled study
dc.subjectelevated plus maze test
dc.subjectfemale
dc.subjecthearing
dc.subjecthippocampus
dc.subjectlatent period
dc.subjectmale
dc.subjectnoise
dc.subjectnonhuman
dc.subjectopen field test
dc.subjectpassive avoidance test
dc.subjectrat
dc.titleExposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations
dc.typeArticle


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