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Salivary urease and ADS enzymatic activity as endogenous protection against dental caries in children

dc.contributor.authorMoncada G.
dc.contributor.authorMaureira J.
dc.contributor.authorNeira M.
dc.contributor.authorReyes E.
dc.contributor.authorOliveira Junior O.B.
dc.contributor.authorFaleiros S.
dc.contributor.authorPalma P.
dc.contributor.authorCorsini G.
dc.contributor.authorUgalde C.
dc.contributor.authorGordan V.V.
dc.contributor.authorYevenes I.
dc.date.accessioned2020-09-02T22:23:31Z
dc.date.available2020-09-02T22:23:31Z
dc.date.issued2015
dc.identifier10.17796/1053-4628-39.4.358
dc.identifier.citation39, 4, 358-363
dc.identifier.issn10534628
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5380
dc.descriptionThe aim of this cross sectional study was to evaluate the ureolytic and arginolytic activities of saliva in children and associate them with their caries status. Study design: 65, 8 year old children, were randomly selected. The ureolytic and arginolytic activity of non stimulated saliva was studied and associated with DMFT and dmft index. Saliva of children were sampled under fasting conditions; Children refrained from any oral hygiene procedures during the 12 hours that preceded the sample collection. Caries activity was scored and divided in 3 groups: Group A: Index zero: without lesions; Group B: Moderate Index: 1 to 3 enamel caries lesions; and Group C: High Index: more than 4 dentin caries lesions. Results: DMFT scores were moderate: 0.4(±0.79) and dmft: 2.78(±2.45). Results expressed in μmol/min/mg/protein, for urease activity were statistically significant (p=0.048): Group A= 0.69 (±0.7); Group B= 0.45 (±0.43); and Group C= 0.39 (±0.55). The arginine deiminase activity was not statistically significant (p=0.16): Group A= 2.53 (±1.42), Group B= 2.31 (±1.57) and Group C= 1.97 (±2.0). Conclusion: Higher levels of ureolytic (statistically significant) and arginolytic activity (trend) in saliva were associated with lower DMFT/dmft scores in 8 year old children. There was a higher production of ammonia from the arginine deiminase system than the urease enzyme in saliva (p>0.05).
dc.language.isoen
dc.publisherJournal of Clinical Pediatric Dentistry
dc.subjectADS
dc.subjectArginina
dc.subjectCaries
dc.subjectChildren
dc.subjectDMFT/dmft
dc.subjectUrea
dc.subjectUrease
dc.subjectammonia
dc.subjectarginine deiminase
dc.subjecthydrolase
dc.subjectsaliva protein
dc.subjecturease
dc.subjectchild
dc.subjectcross-sectional study
dc.subjectdeciduous tooth
dc.subjectdental caries
dc.subjectdiet restriction
dc.subjectenzymology
dc.subjectfemale
dc.subjecthealth survey
dc.subjecthuman
dc.subjectmale
dc.subjectpathology
dc.subjectphysiology
dc.subjectsaliva
dc.subjectsocial class
dc.subjectAmmonia
dc.subjectChild
dc.subjectCross-Sectional Studies
dc.subjectDental Caries
dc.subjectDMF Index
dc.subjectFasting
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrolases
dc.subjectMale
dc.subjectPopulation Surveillance
dc.subjectSaliva
dc.subjectSalivary Proteins and Peptides
dc.subjectSocial Class
dc.subjectTooth, Deciduous
dc.subjectUrease
dc.titleSalivary urease and ADS enzymatic activity as endogenous protection against dental caries in children
dc.typeArticle


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