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Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

dc.contributor.authorMonasterio G.
dc.contributor.authorCastillo F.
dc.contributor.authorRojas L.
dc.contributor.authorCafferata E.A.
dc.contributor.authorAlvarez C.
dc.contributor.authorCarvajal P.
dc.contributor.authorNúñez C.
dc.contributor.authorFlores G.
dc.contributor.authorDíaz W.
dc.contributor.authorVernal R.
dc.date.accessioned2020-09-02T22:23:30Z
dc.date.available2020-09-02T22:23:30Z
dc.date.issued2018
dc.identifier10.1111/joor.12649
dc.identifier.citation45, 8, 589-597
dc.identifier.issn0305182X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5376
dc.descriptionIt is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17 and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22 response in the TMJ-OA pathophysiology has not been established. This study aimed to compare the expression of Th1/Th17/Th22-type cytokines, chemokines and chemokine receptors in synovial fluid samples obtained from TMJ-OA or disk displacement with reduction (DDWR) patients. In addition, it aimed to associate these levels with joint pain, imagenological signs of bone degeneration, RANKL production, osteoclastogenesis and osteoclast-induced bone resorption. Higher levels of IL-1β, IL-17 and IL-22 were expressed in TMJ-OA compared with DDWR subjects, and these increased levels significantly correlated with RANKL expression, joint pain and articular bone degeneration. Higher levels of CCR5, CCR6 and CCR7, as well as their respective ligands CCL5 and CCL20, responsible for recruitment of IL-1β, IL-17 and IL-22-producing cells, were over-expressed in TMJ-OA compared with DDWR subjects. Osteoclastogenesis and osteoclast-induced bone resorption were significantly greater in presence of synovial fluid from TMJ-OA compared with DDWR subjects. These data demonstrate that cytokines, CCLs and CCRs associated with the Th1/Th17/Th22 axis of immuno-inflammatory response are involved in TMJ-OA pathogenesis. These findings suggest that IL-22 is involved in the RANKL expression in TMJ-OA, which in turn induces differentiation of osteoclasts and subsequent resorption of sub-chondral bone. © 2018 John Wiley & Sons Ltd
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectbone resorption
dc.subjectchemokines
dc.subjectcytokines
dc.subjectinterleukin-22
dc.subjectRANKL
dc.subjecttemporomandibular osteoarthritis
dc.subjectosteoclast differentiation factor
dc.subjectadult
dc.subjectaged
dc.subjectcell culture
dc.subjectcell differentiation
dc.subjectcytology
dc.subjectfemale
dc.subjecthelper cell
dc.subjecthuman
dc.subjectimmunology
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectosteoarthritis
dc.subjectosteoclast
dc.subjectosteolysis
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectsynovial fluid
dc.subjectT lymphocyte subpopulation
dc.subjecttemporomandibular joint
dc.subjecttemporomandibular joint disorder
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAged
dc.subjectBone Resorption
dc.subjectCell Differentiation
dc.subjectCells, Cultured
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOsteoarthritis
dc.subjectOsteoclasts
dc.subjectRANK Ligand
dc.subjectSynovial Fluid
dc.subjectT-Lymphocyte Subsets
dc.subjectT-Lymphocytes, Helper-Inducer
dc.subjectTemporomandibular Joint
dc.subjectTemporomandibular Joint Disorders
dc.subjectYoung Adult
dc.titleTh1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report
dc.typeArticle


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