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PCSK9 and inflammation: A review of experimental and clinical evidence

dc.contributor.authorMomtazi-Borojeni A.A.
dc.contributor.authorSabouri-Rad S.
dc.contributor.authorGotto A.M.
dc.contributor.authorPirro M.
dc.contributor.authorBanach M.
dc.contributor.authorAwan Z.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:23:29Z
dc.date.available2020-09-02T22:23:29Z
dc.date.issued2019
dc.identifier10.1093/ehjcvp/pvz022
dc.identifier.citation5, 4, 237-245
dc.identifier.issn20556837
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5371
dc.descriptionProprotein convertase subtilisin/kexin Type 9 (PCSK9) is now identified as an important and major player in hypercholesterolaemia and atherosclerosis pathophysiology. PCSK9, through promoting lysosomal degradation of hepatic low-density lipoprotein (LDL) receptor, can decrease the clearance of plasma LDLs, leading to hypercholesterolaemia and consequent atherosclerotic plaque formation. Hypercholesterolaemia has been found to promote systemic and vascular inflammation, which can cause atherosclerotic lesion formation and progression and subsequent incidence of cardiovascular disease. Recent studies have shown the involvement of PCSK9 in the inflammatory pathway of atherosclerosis. Although trials with PCSK9 inhibitors have not shown any alteration in plasma C-reactive protein levels, there is accumulating evidence showing lessened inflammatory response in the arterial wall that could attenuate atherosclerotic plaque development beyond the established LDL-lowering effect of PCSK9 inhibition. In this review, we represent mounting evidence indicating that PCSK9 can locally increase vascular inflammation and contribute to atherosclerotic plaque progression in patients with hypercholesterolaemia. © 2019 Published on behalf of the European Society of Cardiology. All rights reserved.
dc.language.isoen
dc.publisherOxford University Press
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectLDL-C
dc.subjectLDLR
dc.subjectPCSK9
dc.subjectbococizumab
dc.subjectC reactive protein
dc.subjectcytokine
dc.subjectfibrinogen
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectlow density lipoprotein cholesterol
dc.subjectoxidized low density lipoprotein
dc.subjectplacebo
dc.subjectproprotein convertase 9
dc.subjectrg 7652
dc.subjectserine proteinase inhibitor
dc.subjectunclassified drug
dc.subjectantiinflammatory agent
dc.subjectautacoid
dc.subjectC reactive protein
dc.subjectcytokine
dc.subjecthypocholesterolemic agent
dc.subjectPCSK9 protein, human
dc.subjectproprotein convertase 9
dc.subjectserine proteinase inhibitor
dc.subjectatherogenesis
dc.subjectatheroma
dc.subjectatherosclerotic plaque
dc.subjectcardiovascular disease
dc.subjectcoronary artery disease
dc.subjectcytokine production
dc.subjectenzyme activity
dc.subjectenzyme analysis
dc.subjectgene expression
dc.subjecthuman
dc.subjecthypercholesterolemia
dc.subjectinflammation
dc.subjectleukocyte count
dc.subjectnonhuman
dc.subjectoutcome assessment
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectprotein function
dc.subjectReview
dc.subjectsepsis
dc.subjectsignal transduction
dc.subjectvasculitis
dc.subjectanimal
dc.subjectatherosclerosis
dc.subjectatherosclerotic plaque
dc.subjectenzymology
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectpathology
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectAnticholesteremic Agents
dc.subjectAtherosclerosis
dc.subjectC-Reactive Protein
dc.subjectCytokines
dc.subjectHumans
dc.subjectInflammation
dc.subjectInflammation Mediators
dc.subjectPlaque, Atherosclerotic
dc.subjectProprotein Convertase 9
dc.subjectSerine Proteinase Inhibitors
dc.subjectSignal Transduction
dc.titlePCSK9 and inflammation: A review of experimental and clinical evidence
dc.typeReview


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