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Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent

dc.contributor.authorMohammadi A.
dc.contributor.authorBlesso C.N.
dc.contributor.authorBarreto G.E.
dc.contributor.authorBanach M.
dc.contributor.authorMajeed M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:23:04Z
dc.date.available2020-09-02T22:23:04Z
dc.date.issued2019
dc.identifier10.1016/j.jnutbio.2018.12.005
dc.identifier.citation66, , 1-16
dc.identifier.issn09552863
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5357
dc.descriptionMonocytes and macrophages are important cells of the innate immune system that have diverse functions, including defense against invading pathogens, removal of dead cells by phagocytosis, antigen presentation in the context of MHC class I and class II molecules, and production of various pro-inflammatory cytokines and chemokines such as IL-1β IL-6, TNF-α and MCP-1. In addition, pro-inflammatory (M1) and anti-inflammatory (M2) macrophages clearly play important roles in the progression of several inflammatory diseases. Therefore, therapies that target macrophage polarization and function by either blocking their trafficking to sites of inflammation, or skewing M1 to M2 phenotype polarization may hold clinical promise in several inflammatory diseases. Dietary-derived polyphenols have potent natural anti-oxidative properties. Within this group of polyphenols, curcumin has been shown to suppress macrophage inflammatory responses. Curcumin significantly reduces co-stimulatory molecules and also inhibits MAPK activation and the translocation of NF-κB p65. Curcumin can also polarize/repolarize macrophages toward the M2 phenotype. Curcumin-treated macrophages have been shown to be highly efficient at antigen capture and endocytosis via the mannose receptor. These novel findings provide new perspectives for the understanding of the immunopharmacological role of curcumin, as well as its therapeutic potential for impacting macrophage polarization and function in the context of inflammation-related disease. However, the precise effects of curcumin on the migration, differentiation, polarization and immunostimulatory functions of macrophages remain unknown. Therefore, in this review, we summarized whether curcumin can influence macrophage polarization, surface molecule expression, cytokine and chemokine production and their underlying pathways in the prevention of inflammatory diseases. © 2018 Elsevier Inc.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectCurcumin
dc.subjectCytokine
dc.subjectDietary polyphenols
dc.subjectImmune system
dc.subjectInflammation
dc.subjectMacrophage
dc.subjectchemokine
dc.subjectcurcumin
dc.subjectcytokine
dc.subjectlipid
dc.subjectmannose receptor
dc.subjectnitric oxide
dc.subjectprostaglandin
dc.subjecttoll like receptor
dc.subjectallergy
dc.subjectAlzheimer disease
dc.subjectantigen presentation
dc.subjectasthma
dc.subjectatherosclerosis
dc.subjectbiological activity
dc.subjectcell migration
dc.subjectcell plasticity
dc.subjectcytokine production
dc.subjecthuman
dc.subjectinflammation
dc.subjectinflammatory disease
dc.subjectliver fibrosis
dc.subjectmacrophage
dc.subjectmacrophage function
dc.subjectmalaria
dc.subjectmalignant neoplasm
dc.subjectmetabolic disorder
dc.subjectmycobacteriosis
dc.subjectnonhuman
dc.subjectobesity
dc.subjectpolarization
dc.subjectpregnancy
dc.subjectprotein expression
dc.subjectReview
dc.subjecttumor immunity
dc.titleMacrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent
dc.typeReview


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