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Effects of estrogens and androgens on mitochondria under normal and pathological conditions

dc.contributor.authorMohajeri M.
dc.contributor.authorMartín-Jiménez C.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:23:04Z
dc.date.available2020-09-02T22:23:04Z
dc.date.issued2019
dc.identifier10.1016/j.pneurobio.2019.03.001
dc.identifier.citation176, , 54-72
dc.identifier.issn03010082
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5354
dc.descriptionSeveral lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated with deleterious effects on brain function and progression to neurodegenerative diseases. Recent in vitro and in vivo evidence provides the basis for this review on the interplay of sex steroids and mitochondrial defects in preventing or improving pathological events in the central nervous system (CNS). In this article, the role of mitochondria under normal and pathological states will be discussed. In addition, we will review studies conducted on steroidal compounds, which have neuroprotective effects targeting mitochondria. It has been shown that these compounds could exert both direct and indirect effects on mitochondria that promote or preserve mitochondrial function under pathological circumstances, such as acute brain injury and chronic neurodegeneration. © 2019 Elsevier Ltd
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectAcute
dc.subjectAndrogens
dc.subjectBrain
dc.subjectdiseases
dc.subjectEstrogens
dc.subjectinjury
dc.subjectMitochondria
dc.subjectNeurodegenerative
dc.subjectandrogen
dc.subjectestradiol
dc.subjectestrogen
dc.subjectestrogen receptor alpha
dc.subjectestrogen receptor beta
dc.subjectraloxifene
dc.subjecttamoxifen
dc.subjecttestosterone
dc.subjecttibolone
dc.subjectandrogen
dc.subjectestrogen
dc.subjectneuroprotective agent
dc.subjectAlzheimer disease
dc.subjectamyotrophic lateral sclerosis
dc.subjectbrain cell
dc.subjectbrain injury
dc.subjectcell death
dc.subjectcerebrovascular accident
dc.subjectchronic disease
dc.subjectdrug mechanism
dc.subjectenergy yield
dc.subjectFriedreich ataxia
dc.subjecthuman
dc.subjectHuntington chorea
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectmitochondrion
dc.subjectnerve degeneration
dc.subjectneurologic disease
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectpriority journal
dc.subjectReview
dc.subjectanimal
dc.subjectdegenerative disease
dc.subjectdrug effect
dc.subjectfemale
dc.subjectmale
dc.subjectmetabolism
dc.subjectmitochondrion
dc.subjectAndrogens
dc.subjectAnimals
dc.subjectBrain Injuries
dc.subjectEstrogens
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMitochondria
dc.subjectNerve Degeneration
dc.subjectNeurodegenerative Diseases
dc.subjectNeuroprotective Agents
dc.titleEffects of estrogens and androgens on mitochondria under normal and pathological conditions
dc.typeReview


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