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Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission

dc.contributor.authorMira R.G.
dc.contributor.authorLira M.
dc.contributor.authorTapia-Rojas C.
dc.contributor.authorRebolledo D.L.
dc.contributor.authorQuintanilla R.A.
dc.contributor.authorCerpa W.
dc.date.accessioned2020-09-02T22:23:00Z
dc.date.available2020-09-02T22:23:00Z
dc.date.issued2020
dc.identifier10.3389/fnbeh.2019.00288
dc.identifier.citation13, , -
dc.identifier.issn16625153
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5336
dc.descriptionProblematic alcohol drinking and alcohol dependence are an increasing health problem worldwide. Alcohol abuse is responsible for approximately 5% of the total deaths in the world, but addictive consumption of it has a substantial impact on neurological and memory disabilities throughout the population. One of the better-studied brain areas involved in cognitive functions is the hippocampus, which is also an essential brain region targeted by ethanol. Accumulated evidence in several rodent models has shown that ethanol treatment produces cognitive impairment in hippocampal-dependent tasks. These adverse effects may be related to the fact that ethanol impairs the cellular and synaptic plasticity mechanisms, including adverse changes in neuronal morphology, spine architecture, neuronal communication, and finally an increase in neuronal death. There is evidence that the damage that occurs in the different brain structures is varied according to the stage of development during which the subjects are exposed to ethanol, and even much earlier exposure to it would cause damage in the adult stage. Studies on the cellular and cognitive deficiencies produced by alcohol in the brain are needed in order to search for new strategies to reduce alcohol neuronal toxicity and to understand its consequences on memory and cognitive performance with emphasis on the crucial stages of development, including prenatal events to adulthood. © Copyright © 2020 Mira, Lira, Tapia-Rojas, Rebolledo, Quintanilla and Cerpa.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectalcohol dependence
dc.subjectglutamatergic synaptic transmission
dc.subjecthippocampus
dc.subjectneuronal toxicity
dc.subjectplasticity
dc.subjectalcohol
dc.subjectadulthood
dc.subjectalcohol abuse
dc.subjectalcohol consumption
dc.subjectalcoholism
dc.subjectbrain nerve cell
dc.subjectcell death
dc.subjectcell plasticity
dc.subjectcell structure
dc.subjectcognition
dc.subjectdrinking behavior
dc.subjectGABAergic transmission
dc.subjectglutamatergic synapse
dc.subjecthippocampus
dc.subjecthuman
dc.subjectmemory disorder
dc.subjectmental performance
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectperinatal development
dc.subjectprenatal development
dc.subjectReview
dc.subjectsynaptic transmission
dc.subjecttask performance
dc.subjecttemporal lobe
dc.titleEffect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
dc.typeReview


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