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The role of bone marrow mononuclear cell-conditioned medium in the proliferation and migration of human dermal fibroblasts

dc.contributor.authorMenéndez-Menéndez Y.
dc.contributor.authorOtero-Hernández J.
dc.contributor.authorVega J.A.
dc.contributor.authorPérez-Basterrechea M.
dc.contributor.authorPérez-López S.
dc.contributor.authorÁlvarez-Viejo M.
dc.contributor.authorFerrero-Gutiérrez A.
dc.date.accessioned2020-09-02T22:22:57Z
dc.date.available2020-09-02T22:22:57Z
dc.date.issued2017
dc.identifier10.1186/s11658-017-0055-z
dc.identifier.citation22, 1, -
dc.identifier.issn14258153
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5314
dc.descriptionBackground: Several recent studies have demonstrated the great potential of bone marrow cells in regenerative medicine, not only for their ability to differentiate to match a damaged cell type, but also because they synthesize and release various growth factors and cytokines. We examined the effect of bone marrow cell-conditioned medium in the healing process, especially in terms of fibroblast proliferation and migration. Methods: These in vitro studies consisted of co-culture (without direct contact) of dermal fibroblasts with mononuclear bone marrow cells and the use of conditioned medium obtained from these cultures in a scratch wound model. Results: Mononuclear cells were found to increase the proliferation of fibroblasts, and the conditioned medium showed a stimulatory effect on the migration of fibroblasts. Conclusion: When considered together with the observed increase in growth factor levels in conditioned medium, it appears that these cells act through a paracrine mechanism. © 2017 The Author(s).
dc.language.isoen
dc.publisherSpringer International Publishing
dc.subjectBone marrow mononuclear cells
dc.subjectCell migration and proliferation
dc.subjectHuman dermal fibroblasts
dc.subjectParacrine interactions
dc.subjectWound repair
dc.subjectadult
dc.subjectArticle
dc.subjectbone marrow derived mononuclear cell
dc.subjectcell culture
dc.subjectcell isolation
dc.subjectcell migration
dc.subjectcell proliferation
dc.subjectcell stimulation
dc.subjectclinical article
dc.subjectcoculture
dc.subjectcontrolled study
dc.subjectflow cytometry
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectin vitro study
dc.subjectmesenchymal stem cell
dc.subjectparacrine signaling
dc.subjectskin fibroblast
dc.subjectwound healing
dc.subjectbone marrow cell
dc.subjectcell motion
dc.subjectcell proliferation
dc.subjectconditioned medium
dc.subjectcytology
dc.subjectdermis
dc.subjectdrug effect
dc.subjectfibroblast
dc.subjectmetabolism
dc.subjectmononuclear cell
dc.subjectpharmacology
dc.subjectsolubility
dc.subjectAdult
dc.subjectBone Marrow Cells
dc.subjectCell Movement
dc.subjectCell Proliferation
dc.subjectCulture Media, Conditioned
dc.subjectDermis
dc.subjectFibroblasts
dc.subjectHumans
dc.subjectLeukocytes, Mononuclear
dc.subjectSolubility
dc.subjectWound Healing
dc.titleThe role of bone marrow mononuclear cell-conditioned medium in the proliferation and migration of human dermal fibroblasts
dc.typeArticle


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