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Periostin, dentin matrix protein 1 and P2rx7 ion channel in human teeth and periodontal ligament

dc.contributor.authorMenéndez-Diaz I.
dc.contributor.authorMuriel J.D.
dc.contributor.authorGarcía-Suárez O.
dc.contributor.authorObaya A.
dc.contributor.authorCal S.
dc.contributor.authorCobo J.
dc.contributor.authorVega J.A.
dc.contributor.authorCobo T.
dc.date.accessioned2020-09-02T22:22:57Z
dc.date.available2020-09-02T22:22:57Z
dc.date.issued2018
dc.identifier10.1016/j.aanat.2017.12.004
dc.identifier.citation216, , 103-111
dc.identifier.issn09409602
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5312
dc.descriptionThe periostin is a matricellular protein present in the human periodontal ligament and human dental pulp-derived cells lines, that up-regulates the in vitro expression of some genes involved in the dentin mineralization, such as dentin matrix protein 1 and P2x7-ion channel receptor. Here we investigated the distribution of periostin in human teeth and periodontal ligaments, mapping in parallel the localization of dentin matrix protein 1 and P2x7-ion channel receptor to establish whether or not they are expressed in the same places as periostin. The periodontal ligament and the subodontoblastic layer of the dental pulp displayed strong periostin immunoreactivity, whereas dentin matrix protein 1 was detected in the periodontal ligament co-localized with periostin in the vicinity of the cement. The P2x7 ion channel receptor was regularly absent in both the periodontal ligament and dental tissues, but in some cases, it was observed in the odontoblasts. Present results demonstrate the occurrence of periostin in the healthy adult human tooth without co-localization with proteins involved in tooth mineralization, the expression of which it regulates. These results might serve as a baseline for future studies on pathological conditions. © 2017 Elsevier GmbH
dc.language.isoen
dc.publisherElsevier GmbH
dc.subjectDentin matrix protein 1
dc.subjectHuman
dc.subjectMatricellular proteins
dc.subjectP2x7 ion channel receptor
dc.subjectPeriostin
dc.subjectTooth
dc.subjectdentin matrix protein 1
dc.subjectpurinergic P2X7 receptor
dc.subjecttooth cement
dc.subjecttranscription factor RUNX2
dc.subjectcell adhesion molecule
dc.subjectDMP1 protein, human
dc.subjectP2RX7 protein, human
dc.subjectphosphoprotein
dc.subjectPOSTN protein, human
dc.subjectpurinergic P2X7 receptor
dc.subjectscleroprotein
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectimmunofluorescence
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmale
dc.subjectodontoblast
dc.subjectperiodontal ligament
dc.subjectprotein analysis
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectprotein localization
dc.subjectprotein synthesis regulation
dc.subjecttooth
dc.subjecttooth development
dc.subjecttooth pulp
dc.subjecttooth tissue
dc.subjectchemistry
dc.subjectmetabolism
dc.subjectperiodontal ligament
dc.subjecttooth
dc.subjecttooth cementum
dc.subjectyoung adult
dc.subjectAdult
dc.subjectCell Adhesion Molecules
dc.subjectDental Cementum
dc.subjectDental Pulp
dc.subjectExtracellular Matrix Proteins
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectOdontoblasts
dc.subjectPeriodontal Ligament
dc.subjectPhosphoproteins
dc.subjectReceptors, Purinergic P2X7
dc.subjectTooth
dc.subjectYoung Adult
dc.titlePeriostin, dentin matrix protein 1 and P2rx7 ion channel in human teeth and periodontal ligament
dc.typeArticle


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