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Risk factors for tuberculosis in inflammatory bowel disease: Anti-tumor necrosis factor and hospitalization

dc.contributor.authorMenéndez S.R.
dc.contributor.authorde Francisco R.
dc.contributor.authorArias-Guillén M.
dc.contributor.authorSaro C.
dc.contributor.authorGarcía-Alvarado M.
dc.contributor.authorDuque J.M.
dc.contributor.authorPalacios J.J.
dc.contributor.authorMuñoz F.
dc.contributor.authorBlanco L.
dc.contributor.authorCastaño O.
dc.contributor.authorPérez-Martínez I.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorPérez-Hernández D.
dc.contributor.authorSuárez A.
dc.date.accessioned2020-09-02T22:22:56Z
dc.date.available2020-09-02T22:22:56Z
dc.date.issued2016
dc.identifier10.17235/reed.2016.4440/2016
dc.identifier.citation108, 9, 541-549
dc.identifier.issn11300108
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5310
dc.descriptionAims: To determine risk factors for active tuberculosis in patients with inflammatory bowel diseases. Methods: Retrospective, case-control study at 4 referral hospitals in Spain. Cases developed tuberculosis after a diagnosis of inflammatory bowel disease. Controls were inflammatory bowel disease patients who did not develop tuberculosis. For each case, we randomly selected 3 controls matched for sex, age (within 5 years) and time of inflammatory bowel disease diagnosis (within 3 years). Inflammatory bowel disease characteristics, candidate risk factors for tuberculosis and information about the tuberculosis episode were recorded. Multivariate analysis and a Chi-squared automatic interaction detector were used. Results: Thirty-four cases and 102 controls were included. Nine of the 34 cases developed active tuberculosis between 1989 and 1999, and 25 became ill between 2000 and 2012. Multivariate regression showed an association between active tuberculosis and anti-TNF (tumor necrosis factor) therapy in the previous 12 months (OR 7.45; 95% CI, 2.39-23.12; p = 0.001); hospitalization in the previous 6 months (OR 4.38; 95% CI, 1.18-16.20; p = 0.027); and albumin levels (OR 0.88; 95% CI, 0.81-0.95; p = 0.001). The median time between the start of biologic therapy and the onset of active tuberculosis was 13 (interquartile range, 1-58) months. Tuberculosis developed after a year of anti-TNF therapy in 53%, and late reactivation occurred in at least 3 of 8 patients. Conclusions: The main risks factors for developing tuberculosis were anti-TNF therapy and hospitalization. Over half the cases related to anti-TNF treatment occurred after a year. © 2016. SEPD y ARÁN EDICIONES, S.L.
dc.language.isoen
dc.publisherARAN Ediciones S.A.
dc.subjectAnti-TNF
dc.subjectHospitalization
dc.subjectInflammatory bowel disease
dc.subjectRisk factors
dc.subjectTuberculosis
dc.subjectadalimumab
dc.subjectcorticosteroid
dc.subjectinfliximab
dc.subjecttumor necrosis factor inhibitor
dc.subjectadalimumab
dc.subjectinfliximab
dc.subjectmonoclonal antibody
dc.subjecttumor necrosis factor
dc.subjectadult
dc.subjectalbumin blood level
dc.subjectArticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcoughing
dc.subjectdyspnea
dc.subjectfemale
dc.subjectfever
dc.subjecthospitalization
dc.subjecthuman
dc.subjectimmunosuppressive treatment
dc.subjectinflammatory bowel disease
dc.subjectlength of stay
dc.subjectmalaise
dc.subjectmale
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectthorax pain
dc.subjectthorax radiography
dc.subjecttuberculosis
dc.subjectadolescent
dc.subjectantagonists and inhibitors
dc.subjectcase control study
dc.subjectcomplication
dc.subjecthospitalization
dc.subjectInflammatory Bowel Diseases
dc.subjectmiddle aged
dc.subjectrisk factor
dc.subjectSpain
dc.subjectstatistics and numerical data
dc.subjecttuberculosis
dc.subjectyoung adult
dc.subjectAdalimumab
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntibodies, Monoclonal
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHospitalization
dc.subjectHumans
dc.subjectInflammatory Bowel Diseases
dc.subjectInfliximab
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectSpain
dc.subjectTuberculosis
dc.subjectTumor Necrosis Factor-alpha
dc.subjectYoung Adult
dc.titleRisk factors for tuberculosis in inflammatory bowel disease: Anti-tumor necrosis factor and hospitalization
dc.typeArticle


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