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Intravenous Administration of Functionalized Magnetic Iron Oxide Nanoparticles Does Not Induce CNS Injury in the Rat: Influence of Spinal Cord Trauma and Cerebrolysin Treatment

dc.contributor.authorMenon P.K.
dc.contributor.authorSharma A.
dc.contributor.authorLafuente J.V.
dc.contributor.authorMuresanu D.F.
dc.contributor.authorAguilar Z.P.
dc.contributor.authorWang Y.A.
dc.contributor.authorPatnaik R.
dc.contributor.authorMössler H.
dc.contributor.authorSharma H.S.
dc.date.accessioned2020-09-02T22:22:56Z
dc.date.available2020-09-02T22:22:56Z
dc.date.issued2017
dc.identifier10.1016/bs.irn.2017.08.005
dc.identifier.citation137, , 47-63
dc.identifier.issn00747742
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5309
dc.descriptionInfluence of iron oxide magnetic nanoparticles (IOMNPs, 10 nm in diameter, 0.25 or 0.50 mg/mL in 100 μL, i.v.) on the blood–brain barrier (BBB) permeability, edema formation, and neuronal or glial changes within 4–24 h after administration was examined in normal rats and after a focal spinal cord injury (SCI). Furthermore, effect of cerebrolysin, a balanced composition of several neurotrophic factors, and active peptide fragments was also evaluated on IOMNP-induced changes in central nervous system (CNS) pathology. The SCI was inflicted in rats by making a longitudinal incision into the right dorsal horn of the T10–11 segments and allowed to survive 4 or 24 h after trauma. Cerebrolysin (2.5 mL/kg, i.v.) was given either 30 min before IOMNP injection in the 4-h SCI group or 4 h after injury in the 24-h survival groups. Control group received cerebrolysin in identical situation following IOMNP administration. In all groups, leakage of serum albumin in the CNS as a marker of BBB breakdown and activation of astrocytes using glial fibrillary acidic protein was evaluated by immunohistochemistry. The neuronal injury was examined by Nissl staining. The IOMNPs alone in either low or high doses did not induce CNS pathology either following 4 or 24 h after administration. However, administration of IOMNPs in SCI group slightly enhanced the pathological changes in the CNS after 24 h but not 4 h after trauma. Cerebrolysin treatment markedly attenuated IOMNP-induced aggravation of SCI-induced cord pathology and induced significant neuroprotection. These observations are the first to show that IOMNPs are safe for the CNS and cerebrolysin treatment prevented CNS pathology following a combination of trauma and IOMNP injection. This indicated that cerebrolysin might be used as adjunct therapy during IOMNP administration in disease conditions, not reported earlier. © 2017 Elsevier Inc.
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectAdjunct therapy
dc.subjectBlood–brain barrier
dc.subjectCerebrolysin
dc.subjectIron oxide magnetic nanoparticles
dc.subjectNeuroprotection
dc.subjectSpinal cord injury
dc.subjectalbumin
dc.subjectcerebrolysin
dc.subjectglial fibrillary acidic protein
dc.subjectsuperparamagnetic iron oxide nanoparticle
dc.subjectamino acid
dc.subjectcerebrolysin
dc.subjectferric ion
dc.subjectferric oxide
dc.subjectglial fibrillary acidic protein
dc.subjectnanoparticle
dc.subjectneuroprotective agent
dc.subjectalbumin blood level
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectastrocyte
dc.subjectblood brain barrier
dc.subjectcell activation
dc.subjectcontrolled study
dc.subjectexperimental CNS injury
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectneuroprotection
dc.subjectNissl staining
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectspinal cord injury
dc.subjectanimal
dc.subjectchemically induced
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectintravenous drug administration
dc.subjectmetabolism
dc.subjectnerve cell
dc.subjectpathology
dc.subjectspinal cord injury
dc.subjectSprague Dawley rat
dc.subjecttreatment outcome
dc.subjectAdministration, Intravenous
dc.subjectAmino Acids
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectFerric Compounds
dc.subjectGlial Fibrillary Acidic Protein
dc.subjectMale
dc.subjectNanoparticles
dc.subjectNeurons
dc.subjectNeuroprotective Agents
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSpinal Cord Injuries
dc.subjectTreatment Outcome
dc.titleIntravenous Administration of Functionalized Magnetic Iron Oxide Nanoparticles Does Not Induce CNS Injury in the Rat: Influence of Spinal Cord Trauma and Cerebrolysin Treatment
dc.typeBook Chapter


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