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Role of neuroinflammation and sex hormones in war-related PTSD

dc.contributor.authorMendoza C.
dc.contributor.authorBarreto G.E.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:22:55Z
dc.date.available2020-09-02T22:22:55Z
dc.date.issued2016
dc.identifier10.1016/j.mce.2016.05.016
dc.identifier.citation434, , 266-277
dc.identifier.issn03037207
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5299
dc.descriptionThe susceptibility to develop posttraumatic stress disorder (PTSD) is greatly influenced by both innate and environmental risk factors. One of these factors is gender, with women showing higher incidence of trauma-related mental health disorders than their male counterparts. The evidence so far links these differences in susceptibility or resilience to trauma to the neuroprotective actions of sex hormones in reducing neuroinflammation after severe stress exposure. In this review, we discuss the impact of war-related trauma on the incidence of PTSD in civilian and military populations as well as differences associated to gender in the incidence and recovery from PTSD. In addition, the mutually influencing role of inflammation, genetic, and sex hormones in modulating the consequences derived from exposure to traumatic events are discussed in light of current evidence. © 2016
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectCombat PTSD
dc.subjectFear
dc.subjectNeuroinflammation
dc.subjectSex hormones
dc.subjectStress
dc.subjectTrauma
dc.subjectpropranolol
dc.subjectsex hormone
dc.subjectstress hormone
dc.subjectsex hormone
dc.subjectclinical study
dc.subjectconvalescence
dc.subjectdisease association
dc.subjectdisease course
dc.subjectdrug effect
dc.subjectdrug response
dc.subjectelectroencephalogram
dc.subjectexposure
dc.subjecthormone action
dc.subjecthormone response
dc.subjecthuman
dc.subjecthypothalamus hypophysis gonad system
dc.subjectinnate immunity
dc.subjectmental stress
dc.subjectnervous system inflammation
dc.subjectnonhuman
dc.subjectposttraumatic stress disorder
dc.subjectpriority journal
dc.subjectReview
dc.subjectsex difference
dc.subjectwar
dc.subjectfemale
dc.subjectimmunology
dc.subjectmale
dc.subjectmetabolism
dc.subjectpsychology
dc.subjectStress Disorders, Post-Traumatic
dc.subjectwarfare
dc.subjectFemale
dc.subjectGonadal Steroid Hormones
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectMale
dc.subjectSex Factors
dc.subjectStress Disorders, Post-Traumatic
dc.subjectStress, Psychological
dc.subjectWarfare
dc.titleRole of neuroinflammation and sex hormones in war-related PTSD
dc.typeReview


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