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Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

dc.contributor.authorMendoza C.
dc.contributor.authorBarreto G.E.
dc.contributor.authorIarkov A.
dc.contributor.authorTarasov V.V.
dc.contributor.authorAliev G.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:22:55Z
dc.date.available2020-09-02T22:22:55Z
dc.date.issued2018
dc.identifier10.1007/s12035-018-0869-3
dc.identifier.citation55, 8, 6700-6711
dc.identifier.issn15591182
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5298
dc.descriptionPost-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.
dc.language.isoen
dc.publisherNLM (Medline)
dc.subjectCotinine
dc.subjectExtinction
dc.subjectFear
dc.subjectInflammation
dc.subjectNicotinic receptor
dc.subjectPost-traumatic stress disorder
dc.subjectcotinine
dc.subjectnicotinic receptor
dc.subjectanimal
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmemory
dc.subjectmetabolism
dc.subjectnerve cell plasticity
dc.subjectposttraumatic stress disorder
dc.subjectpsychology
dc.subjectreinforcement
dc.subjectAnimals
dc.subjectCotinine
dc.subjectExtinction, Psychological
dc.subjectHumans
dc.subjectMemory
dc.subjectNeuronal Plasticity
dc.subjectReceptors, Nicotinic
dc.subjectStress Disorders, Post-Traumatic
dc.titleCotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder
dc.typeReview


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