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Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

dc.contributor.authorMendoza C.
dc.contributor.authorBarreto G.E.
dc.contributor.authorIarkov A.
dc.contributor.authorTarasov V.V.
dc.contributor.authorAliev G.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:22:55Z
dc.date.available2020-09-02T22:22:55Z
dc.date.issued2018
dc.identifier10.1007/s12035-018-0869-3
dc.identifier.citation55, 8, 6700-6711
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5297
dc.descriptionPost-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectCotinine
dc.subjectExtinction
dc.subjectFear
dc.subjectInflammation
dc.subjectNicotinic receptor
dc.subjectPost-traumatic stress disorder
dc.subjectcotinine
dc.subjectnicotinic receptor
dc.subjectbrain region
dc.subjectfear
dc.subjectfunctional connectivity
dc.subjecthuman
dc.subjectmemory
dc.subjectmental stress
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectposttraumatic stress disorder
dc.subjectpsychotherapy
dc.subjectreinforcement
dc.subjectReview
dc.titleCotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder
dc.typeReview


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