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Medicinal plants as protective strategies against parkinson’s disease

dc.contributor.authorMazo N.A.
dc.contributor.authorEcheverria V.
dc.contributor.authorCabezas R.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorTarasov V.V.
dc.contributor.authorYarla N.S.
dc.contributor.authorAliev G.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:22:53Z
dc.date.available2020-09-02T22:22:53Z
dc.date.issued2017
dc.identifier10.2174/1381612823666170316142803
dc.identifier.citation23, 28, 4180-4188
dc.identifier.issn13816128
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5280
dc.descriptionParkinson’s disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-kB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectDopaminergic neurons
dc.subjectNeuroprotective fruits
dc.subjectParkinson’s disease
dc.subjectPhytochemicals
dc.subjectSignaling pathways
dc.subjectTranscription factors
dc.subjectanthocyanin
dc.subjectDOPA decarboxylase inhibitor
dc.subjectflavone derivative
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectisothiocyanic acid
dc.subjectlevodopa
dc.subjectluteolin
dc.subjectmitogen activated protein kinase
dc.subjectnaringenin
dc.subjectnobiletin
dc.subjectplant medicinal product
dc.subjectpolymethoxylflavone
dc.subjectreactive oxygen metabolite
dc.subjectsulforaphane
dc.subjecttranscription factor
dc.subjecttranscription factor Nrf2
dc.subjectunclassified drug
dc.subjectantioxidant
dc.subjectantiparkinson agent
dc.subjectfree radical
dc.subjectneuroprotective agent
dc.subjectplant medicinal product
dc.subjectreactive oxygen metabolite
dc.subjectaging
dc.subjectantiinflammatory activity
dc.subjectbiosynthesis
dc.subjectcell survival
dc.subjectdevelopmental delay
dc.subjectdopaminergic nerve cell
dc.subjectfruit
dc.subjecthuman
dc.subjectmedicinal plant
dc.subjectnervous system inflammation
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectParkinson disease
dc.subjectPi3K/Akt signaling
dc.subjectpriority journal
dc.subjectprotein degradation
dc.subjectReview
dc.subjectrisk factor
dc.subjecttherapy effect
dc.subjectanimal
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectisolation and purification
dc.subjectmedicinal plant
dc.subjectmetabolism
dc.subjectParkinson disease
dc.subjectpathophysiology
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectAntiparkinson Agents
dc.subjectDopaminergic Neurons
dc.subjectFree Radicals
dc.subjectHumans
dc.subjectNeuroprotective Agents
dc.subjectOxidative Stress
dc.subjectParkinson Disease
dc.subjectPlant Preparations
dc.subjectPlants, Medicinal
dc.subjectReactive Oxygen Species
dc.titleMedicinal plants as protective strategies against parkinson’s disease
dc.typeReview


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